Publications related to Illegal drug trade

Systematic mapping of antibiotic cross-resistance and collateral sensitivity with chemical genetics

Camille Véronique Bernadette Goemans, Florian Huber

By acquiring or evolving resistance to one antibiotic, bacteria can become resistant to a second one, due to shared underlying mechanisms. This is called cross-resistance (XR) and further limits therapeutic choices. The opposite scenario, in which initial ...

2024

The predictive capacity of in vitro preclinical models to evaluate drugs for the treatment of retinoblastoma

Paul Joseph Dyson, Irina Sinenko, Roland Christopher Turnell-Ritson

Retinoblastoma is a rare childhood cancer of the eye. Of the small number of drugs are used to treat retinoblastoma, all have been repurposed from drugs developed for other conditions. In order to find drugs or drug combinations better suited to the improv ...

ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD2023

Translational screening platform to evaluate chemotherapy in combination with focal therapy for retinoblastoma

Paul Joseph Dyson, Valentin Simeonov, Fabien Kuttler, Irina Sinenko, Patrik Aouad

Retinoblastoma is the most common pediatric eye cancer. It is currently treated with a limited number of drugs, adapted from other pediatric cancer treatments. Drug toxicity and relapse of the disease warrant new therapeutic strategies for these young pati ...

WILEY2023

Effective Inhibition of TDP-43 Aggregation by Native State Stabilization

Hilal Lashuel, Yllza Jasiqi, Lixin Yang

Preventing the misfolding or aggregation of transactive response DNA binding protein with 43 kDa (TDP-43) is the most actively pursued disease-modifying strategy to treat amyotrophic lateral sclerosis and other neurodegenerative diseases. In this work, we ...

Weinheim2023

Enhancing the Signaling of GPCRs via Orthosteric Ions

Horst Vogel, Shuguang Yuan

G protein-coupled receptors play essential roles in cellular processes such as neuronal signaling, vision, olfaction, tasting, and metabolism. As GPCRs are the most important drug targets, understanding their interactions with ligands is of utmost importan ...

AMER CHEMICAL SOC2020

A wearable electrochemical sensing system for non-invasive monitoring of lithium drug in bipolar disorder

Giovanni De Micheli, Sandro Carrara, Irene Taurino, Francesca Criscuolo

Lithium represents the main drug for the treatment of Bipolar Disorder (BD) as it acts as a mood stabilizer. However, because of its narrow therapeutic window, psychiatric patients are obliged to frequent tests in hospital to control their lithium blood co ...

2020

Preexisting variation in DNA damage response predicts the fate of single mycobacteria under stress

John McKinney, Neeraj Dhar, Giulia Manina, Lalit Kumar Singh

Clonal microbial populations are inherently heterogeneous, and this diversification is often considered as an adaptation strategy. In clinical infections, phenotypic diversity is found to be associated with drug tolerance, which in turn could evolve into g ...

2019

A novel electrochemical sensor for non-invasive monitoring of lithium levels in mood disorders

Giovanni De Micheli, Sandro Carrara, Irene Taurino, Francesca Criscuolo

Lithium is the main drug for the treatment of mood disorders. Due to its narrow therapeutic window, Therapeutic Drug Monitoring (TDM) is a norm during therapy in order to avoid adverse effects. Consequently, patients are obliged to frequent check-ups in ho ...

2018

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Illegal drug trade

Systematic mapping of antibiotic cross-resistance and collateral sensitivity with chemical genetics

The predictive capacity of in vitro preclinical models to evaluate drugs for the treatment of retinoblastoma

Translational screening platform to evaluate chemotherapy in combination with focal therapy for retinoblastoma

Effective Inhibition of TDP-43 Aggregation by Native State Stabilization

Capacitive sensor to monitor the level of drug inside an injector pen

Enhancing the Signaling of GPCRs via Orthosteric Ions

A wearable electrochemical sensing system for non-invasive monitoring of lithium drug in bipolar disorder

Preexisting variation in DNA damage response predicts the fate of single mycobacteria under stress

A novel electrochemical sensor for non-invasive monitoring of lithium levels in mood disorders

Aptamer-based Field-Effect Biosensor for Tenofovir Detection

Graph Chatbot

Chat with Graph Search

Translational screening platform to evaluate chemotherapy in combination with focal therapy for retinoblastoma

Capacitive sensor to monitor the level of drug inside an injector pen

Aptamer-based Field-Effect Biosensor for Tenofovir Detection

Effective Inhibition of TDP-43 Aggregation by Native State Stabilization

A wearable electrochemical sensing system for non-invasive monitoring of lithium drug in bipolar disorder

A novel electrochemical sensor for non-invasive monitoring of lithium levels in mood disorders

The predictive capacity of in vitro preclinical models to evaluate drugs for the treatment of retinoblastoma

Enhancing the Signaling of GPCRs via Orthosteric Ions

Preexisting variation in DNA damage response predicts the fate of single mycobacteria under stress