Nearly neutral theory of molecular evolutionThe nearly neutral theory of molecular evolution is a modification of the neutral theory of molecular evolution that accounts for the fact that not all mutations are either so deleterious such that they can be ignored, or else neutral. Slightly deleterious mutations are reliably purged only when their selection coefficient are greater than one divided by the effective population size. In larger populations, a higher proportion of mutations exceed this threshold for which genetic drift cannot overpower selection, leading to fewer fixation events and so slower molecular evolution.
Evolution of biological complexityThe evolution of biological complexity is one important outcome of the process of evolution. Evolution has produced some remarkably complex organisms – although the actual level of complexity is very hard to define or measure accurately in biology, with properties such as gene content, the number of cell types or morphology all proposed as possible metrics. Many biologists used to believe that evolution was progressive (orthogenesis) and had a direction that led towards so-called "higher organisms", despite a lack of evidence for this viewpoint.
OverdominanceOverdominance is a rare condition in genetics where the phenotype of the heterozygote lies outside the phenotypical range of both homozygous parents. Overdominance can also be described as heterozygote advantage regulated by a single genomic locus, wherein heterozygous individuals have a higher fitness than homozygous individuals. However, not all cases of the heterozygote advantage are considered overdominance, as they may be regulated by multiple genomic regions.
Shifting balance theoryThe shifting balance theory is a theory of evolution proposed in 1932 by Sewall Wright, suggesting that adaptive evolution may proceed most quickly when a population divides into subpopulations with restricted gene flow. The name of the theory is borrowed from Wright's metaphor of fitness landscapes (evolutionary landscapes), attempting to explain how a population may move across an adaptive valley to a higher adaptive peak.
Conservation geneticsConservation genetics is an interdisciplinary subfield of population genetics that aims to understand the dynamics of genes in a population for the purpose of natural resource management and extinction prevention. Researchers involved in conservation genetics come from a variety of fields including population genetics, natural resources, molecular ecology, biology, evolutionary biology, and systematics. Genetic diversity is one of the three fundamental measures of biodiversity (along with species diversity and ecosystem diversity), so it is an important consideration in the wider field of conservation biology.
Mutation–selection balanceMutation–selection balance is an equilibrium in the number of deleterious alleles in a population that occurs when the rate at which deleterious alleles are created by mutation equals the rate at which deleterious alleles are eliminated by selection. The majority of genetic mutations are neutral or deleterious; beneficial mutations are relatively rare. The resulting influx of deleterious mutations into a population over time is counteracted by negative selection, which acts to purge deleterious mutations.
Sampling errorIn statistics, sampling errors are incurred when the statistical characteristics of a population are estimated from a subset, or sample, of that population. It can produced biased results. Since the sample does not include all members of the population, statistics of the sample (often known as estimators), such as means and quartiles, generally differ from the statistics of the entire population (known as parameters). The difference between the sample statistic and population parameter is considered the sampling error.
Evolutionary dynamicsEvolutionary dynamics is the study of the mathematical principles according to which biological organisms as well as cultural ideas evolve and evolved. This is mostly achieved through the mathematical discipline of population genetics, along with evolutionary game theory. Most population genetics considers changes in the frequencies of alleles at a small number of gene loci. When infinitesimal effects at a large number of gene loci are considered, one derives quantitative genetics.
Error threshold (evolution)In evolutionary biology and population genetics, the error threshold (or critical mutation rate) is a limit on the number of base pairs a self-replicating molecule may have before mutation will destroy the information in subsequent generations of the molecule. The error threshold is crucial to understanding "Eigen's paradox". The error threshold is a concept in the origins of life (abiogenesis), in particular of very early life, before the advent of DNA.
Fixation indexThe fixation index (FST) is a measure of population differentiation due to genetic structure. It is frequently estimated from genetic polymorphism data, such as single-nucleotide polymorphisms (SNP) or microsatellites. Developed as a special case of Wright's F-statistics, it is one of the most commonly used statistics in population genetics. Its values range from 0 to 1, with 0.15 being substantially differentiated and 1 being complete differentiation.