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The 5-HT3 serotonin receptor belongs to the cys-loop ligand-gated ion channel (LGIC) family. It is located in the central and peripheral nervous system and is implicated in certain pathologic situations. The 5-HT3 receptor is investigated here, as a typica ...
The dynamics of Hb I (HbI) from the clam Lucina pectinata, from wild-type sperm whale (SW) myoglobin, and from the L29F/H64Q/V68F triple mutant of SW, both unligated and bound to hydrogen sulfide (H2S), have been studied in mol. dynamics simulations. Featu ...
The application describes ligands for binding targets, the ligands preferably including peptides having at least one sulfated or sulfonated amino acid. The ligand preferably specifically binds to heparin binding sites of biomolecules. Compositions, systems ...
The authors present a method for spreading large (> 100 mm2) cell membrane fragments across nanoapertures in planar supports. Electron-beam and focused-ion-beam lithog. were used to fabricate arrays of 50-600 nm diam. holes in free-standing silicon nitride ...
Fluorescence resonance energy transfer (FRET) is a powerful technique to reveal interactions between membrane proteins in live cells. Fluorescence labeling for FRET is typically performed by fusion with fluorescent proteins (FP) with the drawbacks of a lim ...
The Fox-1 protein regulates alternative splicing of tissue-specific exons by binding to GCAUG elements. Here, we report the soln. structure of the Fox-1 RNA binding domain (RBD) in complex with UGCAUGU. The last three nucleotides, UGU, are recognized in a ...
The olfactory system is a highly specialized chemodetector capable of discriminating between thousands of volatile chemical substances. This enormous capacity of chemical recognition is based on a large family of olfactory receptors (ORs). Despite the fact ...
Neutral metallamacrocycles with four or ten metal centers were obtained by reaction of [(R3P)PdCl2]2 with 2,3-dihydroxypyridine and derivatives or 2-hydroxynicotinic acid in the presence of base. In all these assemblies, the two O-donor atoms of the ligand ...
12-Metallacrown-3 complexes were formed by self-assembly of organometallic half-sandwich complexes [(π-ligand)MCl2]2 (M = Ru, Rh, Ir) and 3-hydroxy-2-pyridone ligands in the presence of Cs2CO3 as base. Upon mixing of different macrocycles, reversible metal ...
A novel reactive perstraction system has been developed based on liq.-core capsules, involving an enzyme-catalyzed reaction coupled with simultaneous in situ product recovery. Lipase-catalyzed reactions, hydrolysis of triprionin and nitrophenyl laurate, we ...
