Concept
Amyloid plaques
Related publications (184)
Method of preparation of amyloidogenic protein aggregates and uses thereof
Hilal Lashuel, Galina Limorenko
The invention relates to methods for the preparation of method of preparation of Tau aggregates, including fibrils, fibrillar species, soluble and insoluble oligomeric species, new Tau aggregates and uses thereof. The invention further relates to the uses ...
2024Plasma biomarkers for Alzheimer's disease: a field-test in a memory clinic
Background The key Alzheimer's disease (AD) biomarkers are traditionally measured with techniques/exams that are either expensive (amyloid-positron emission tomography (PET) and tau-PET), invasive (cerebrospinal fluid A beta 42 and p-tau 181), or poorly sp ...
BMJ PUBLISHING GROUP2023Tau seeds from patients induce progressive supranuclear palsy pathology and symptoms in primates
Grégoire Courtine, Tomislav Milekovic, Flavio Raschella
Progressive supranuclear palsy is a primary tauopathy affecting both neurons and glia and is responsible for both motor and cognitive symptoms. Recently, it has been suggested that progressive supranuclear palsy tauopathy may spread in the brain from cell ...
OXFORD UNIV PRESS2022Impact and implications of mixed plaque class in automated characterization of complex atherosclerotic lesions
Atherosclerosis is a complex disease altering vasculature morphology, and subsequently flow, with progressive plaque formation, mural disruption, and lumen occlusion. Determination of clinically-relevant plaque components-particularly calcium, lipid, and f ...
PERGAMON-ELSEVIER SCIENCE LTD2022Lewy body-associated proteins: Victims, instigators, or innocent bystanders? The case of AIMP2 and alpha-synuclein
Hilal Lashuel, Salvatore Novello
Lewy bodies (LBs), one of the neuropathological defining hallmarks of Parkinson's disease (PD), are composed of a complex mixture of alpha-synuclein (aSyn) filaments and hundreds of proteins, lipids, and membranous organelles. However, these proteins' role ...
2021