Concept
Oxytocin
Related publications (33)
Temporal Dynamics of Intranasal Oxytocin in Human Brain Electrophysiology
Patricia Figueiredo, Janir Nuno Ramos Antunes Da Cruz
Oxytocin (OT) is a key modulator of human social cognition, popular in behavioral neuroscience. To adequately design and interpret intranasal OT (IN-OT) research, it is crucial to know for how long it affects human brain function once administered. However ...
OXFORD UNIV PRESS INC2022Long term effects of peripubertal stress on excitatory and inhibitory circuits in the prefrontal cortex of male and female mice
The impact of stressful events is especially important during early life, because certain cortical regions, especially the prefrontal cortex (PFC), are still developing. Consequently, aversive experiences that occur during the peripubertal period can cause ...
ELSEVIER SCIENCE INC2021Brainstem Correlates of a Cold Pressor Test Measured by Ultra-High Field fMRI
Dimitri Nestor Alice Van De Ville, Olivier Benoit Thomas Reynaud, Domenica Bueti, Fatma Megdiche
Introduction Modern imaging techniques such as blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) allow the non-invasive and indirect measurement of brain activity. Whether changes in signal intensity can be detected in small ...
2020Drugs Based on de novo-developed Peptides are Coming of Age
Naturally evolved peptides, such as the hormone oxytocin or the anti-bacterial vancomycin, have seen decades of success as powerful therapeutics due to many of the favorable properties of peptides. Not every desired target has a naturally occurring bioacti ...
SWISS CHEMICAL SOC2018The link between aberrant hypothalamic-pituitary-adrenal axis activity during development and the emergence of aggression-Animal studies
Maria del Carmen Sandi Perez, Damien Sébastien Huzard, Sophie Elizabeth Walker
Aggressive behavior is not uniform, including proactive and reactive forms of aggression. Aberrant functioning of the hypothalamic-pituitary-adrenal (HPA) axis is frequently associated with abnormal aggression. Here, we review the rodent literature in orde ...
2018Stress Impacts the Regulation Neuropeptides in the Rat Hippocampus and Prefrontal Cortex
Gregor Rainer, Laura Lozano Montes, Nan Zhao
Adverse life experience increases the lifetime risk to several stress-related psychopathologies, such as anxiety or depressive–like symptom following stress in adulthood. However, the neurochemical modulations triggered by stress have not been fully charac ...
2018Converting disulfide bridges in native peptides to stable methylene thioacetals
Nicolai Cramer, Christopher Matthew Bandeli Kourra
Disulfide bridges play a crucial role in defining and rigidifying the three-dimensional structure of peptides. However, disulfides are inherently unstable in reducing environments. Consequently, the development of strategies aiming to circumvent these defi ...
Royal Soc Chemistry2016A Preclinical Model for ERα-Positive Breast Cancer Points to the Epithelial Microenvironment as Determinant of Luminal Phenotype and Hormone Response
Cathrin Brisken, Georgios Sflomos, Ayyakkannu Ayyanan, Laura Battista, Maryse Fiche, Valentina Scabia, Valérian Charles Robert Dormoy
Seventy-five percent of breast cancers are estrogen receptor α positive (ER(+)). Research on these tumors is hampered by lack of adequate in vivo models; cell line xenografts require non-physiological hormone supplements, and patient-derived xenografts (PD ...
Elsevier2016Development of Stapling Methods by Selective Side Chain Modifications of Bioactive Peptides
Christopher Matthew Bandeli Kourra
Cyclic peptide therapeutics fill the gap between small molecules (5000 Da) as a separate class of drugs, combining the advantages of both in terms of high selectivity, bioavailability, synthetic accessibility and low toxicity. Howe ...
EPFL2016