Concept

Tazarotene

Related publications (4)

Stereoselective synthesis of 8-oxabicyclo[3.2.1]octane-2,3,4,6,7-pentols and total asymmetric synthesis of 2,6-anhydrohepturonic acid derivatives and of beta-C-manno-pyranosides suitable for the construction of (1 -> 3)-C,C-linked trisaccharides

Enantiomerically pure (+)-(1S4S,5S 6S)-6-endo-(benzyloxy)-5-exo-{[(tert-butyl)dimethylsilyl]oxy}-7-oxa-bicy clo[2.2.1]heptan-2-one ((+)-5) and its enantiomer (-)-5, obtained readily from the Diets-Alder addition of furan to 1-cyanovinyl acetate. can be con ...

2001

Metabolic effects of rexinoids: tissue-specific regulation of lipoprotein lipase activity

Johan Auwerx

Hypertriglyceridemia is a frequent complication accompanying the treatment of patients with either retinoids or rexinoids, [retinoid X receptor (RXR)-selective retinoids]. To investigate the cellular and molecular basis for this observation, we have studie ...

2001

Induction of the fatty acid transport protein 1 and acyl-CoA synthase genes by dimer-selective rexinoids suggests that the peroxisome proliferator-activated receptor-retinoid X receptor heterodimer is their molecular target

Johan Auwerx

The intracellular fatty acid content of insulin-sensitive target tissues determines in part their insulin sensitivity. Uptake of fatty acids into cells is a controlled process determined in part by a regulated import/export system that is controlled at lea ...

2000

Retinoids increase human apolipoprotein A-11 expression through activation of the retinoid X receptor but not the retinoic acid receptor

Johan Auwerx, Kristina Schoonjans

Considering the link between plasma high-density lipoprotein (HDL) cholesterol levels and a protective effect against coronary artery disease as well as the suggested beneficial effects of retinoids on the production of the major HDL apolipoprotein (apo), ...

1996

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