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Total joint replacements are highly successful in relieving pain and restoring movement of damaged joints. However, the lifespan of the implants is limited. The implant's long-term stability depends largely on the preservation of periprosthetic bone. Debri ...
[...] Our findings show that a mutant of PSD-95 that lacks its GK domain clusters along the dendritic shaft and dramatically decreases the spine density without affecting the frequency of miniature excitatory postsynaptic currents (mEPSCs)[... click on "Do ...
It is a clinical challenge to obtain a sufficient orthopedic implant fixation in weak osteoporotic bone. When the primary implant fixation is poor, micromotions occur at the bone-implant interface, activating osteoclasts, which leads to implant loosening. ...
The bone diagnostic instrument (BDI) is being developed with the long-term goal of providing a way for researchers and clinicians to measure bone material properties of human bone in vivo. Such measurements could contribute to the overall assessment of bon ...
Mechanical testing of trabecular bone is mainly motivated by the huge impact of osteoporosis in post-menopausal women and the aged in society in terms of social and health care costs. Trabecular bone loss and impairment of its mechanical properties reduce ...
A combined strategy using bioluminescence imaging, bone densitometry and histology was used to analyze the bone regeneration capacity of human bone marrow (hBMSC) and adipose tissue (hAMSC) mesenchymal stem cells, seeded in an osteoconductive arginine-glyc ...
The mechanical properties of healthy and diseased bone tissue were extensively studied in mechanical tests. Most of this research was motivated by the immense costs of health care and social impacts due to osteoporosis in post-menopausal women and the aged ...
Patients with osteoporosis and joint disabilities represent a constant growing and challenging population to be treated in the musculoskeletal clinical field. Especially in the case of total hip arthroplasty, new solutions should be developed to compensate ...
Tensile tests have been performed on replicated aluminum alloy foams of relative density between 4.5% and 8%. During the test the electrical resistance was measured with a four-point set-up and the displacements along the gage section were measured using a ...
The transcription factor Sox4 is vital for fetal development, as Sox4–/– homozygotes die in utero. Sox4 mRNA is expressed in the early embryonic growth plate and is regulated by parathyroid hormone, but its function in bone modeling/remodeling is unknown. ...