Publications related to Fibril

Cell-mediated Fibre Recruitment Drives Extracellular Matrix Mechanosensing in Engineered Fibrillar Microenvironments

To investigate how cells sense stiffness in settings structurally similar to native extracellular matrices, we designed a synthetic fibrous material with tunable mechanics and user-defined architecture. In contrast to flat hydrogel surfaces, these fibrous ...

Nature Publishing Group2015

Influence of the β-sheet content on the mechanical properties of aggregates during amyloid fibrillization

Giovanni Dietler, Hilal Lashuel, Francesco Simone Ruggeri, Jae Sun Jeong, Raffaele Mezzenga

Amyloid fibrils associated with neurodegenerative diseases, such as Parkinson's and Alzheimer's, consist of insoluble aggregates of α-synuclein and Aβ-42 proteins with a high β-sheet content. The aggregation of both proteins occurs by misfolding of the mon ...

Wiley-Blackwell2015

Fibril growth and seeding capacity play key roles in α-synuclein-mediated apoptotic cell death

Hilal Lashuel, Anne-Laure Mahul Mellier, Nadine Aït Bouziad, Bohumil Maco, Filip Vercruysse

The role of extracellular α-synuclein (α-syn) in the initiation and the spreading of neurodegeneration in Parkinson's disease (PD) has been studied extensively over the past 10 years. However, the nature of the α-syn toxic species and the molecular mechani ...

Nature Publishing Group2015

High aspect ratio nanofibril materials

Jeffrey Alan Hubbell, Carrie Ellen Brubaker

The present invention features linear and three-dimensional supramolecular materials self-assembled from block copolymers comprising oligo(ethylene sulfide) (OES). The block copolymers assemble into fibrils, micelles, or matrices. The fibrillar materials a ...

2015

Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease

Hilal Lashuel, Patrick Fraering, Saviana Di Giovanni, Simona Eleuteri

Aβ accumulation plays a central role in the pathogenesis of Alzheimer's disease (AD). Recent studies suggest that the process of Aβ nucleated polymerization is essential for Aβ fibril formation, pathology spreading and toxicity. Therefore, targeting this p ...

2015

The centriolar protein CPAP G-box: an amyloid fibril in a single domain

Georgios Hatzopoulos

Centrioles are evolutionarily conserved cylindrical cell organelleswith characteristic radial symmetry. Despite their considerable size (400 nm x 200 nm, in humans), genetic studies suggest that relatively few protein components are involved in their assem ...

Portland Press Ltd2015

Infrared nanospectroscopy characterization of oligomeric and fibrillar aggregates during amyloid formation

Giovanni Dietler, Giovanni Longo, Francesco Simone Ruggeri, Ewelina Wioletta Lipiec

Amyloids are insoluble protein fibrillar aggregates. The importance of characterizing their aggregation has steadily increased because of their link to human diseases and material science applications. In particular, misfolding and aggregation of the Josep ...

Nature Publishing Group2015

Long-term Intravital Immunofluorescence Imaging of Tissue Matrix Components with Epifluorescence and Two-photon Microscopy

Melody Swartz, Witold Waldemar Kilarski, Amanda Waite Lund, Manuel Andreas Fankhauser

Besides being a physical scaffold to maintain tissue morphology, the extracellular matrix (ECM) is actively involved in regulating cell and tissue function during development and organ homeostasis. It does so by acting via biochemical, biomechanical, and b ...

Journal Of Visualized Experiments2014

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Fibril

Cell-mediated Fibre Recruitment Drives Extracellular Matrix Mechanosensing in Engineered Fibrillar Microenvironments

Influence of the β-sheet content on the mechanical properties of aggregates during amyloid fibrillization

Recapitulating De Novo Alpha-Synuclein Fibrillization in a Novel Neuronal Model of Parkinson's Disease

Fibril growth and seeding capacity play key roles in α-synuclein-mediated apoptotic cell death

High aspect ratio nanofibril materials

Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease

The centriolar protein CPAP G-box: an amyloid fibril in a single domain

Infrared nanospectroscopy characterization of oligomeric and fibrillar aggregates during amyloid formation

New Insights Into Amyloid Formation and Structure by Innovative Atomic Force Microscopy Methods

Long-term Intravital Immunofluorescence Imaging of Tissue Matrix Components with Epifluorescence and Two-photon Microscopy

Graph Chatbot

Chat with Graph Search

Cell-mediated Fibre Recruitment Drives Extracellular Matrix Mechanosensing in Engineered Fibrillar Microenvironments

Long-term Intravital Immunofluorescence Imaging of Tissue Matrix Components with Epifluorescence and Two-photon Microscopy

New Insights Into Amyloid Formation and Structure by Innovative Atomic Force Microscopy Methods

Influence of the β-sheet content on the mechanical properties of aggregates during amyloid fibrillization

Recapitulating De Novo Alpha-Synuclein Fibrillization in a Novel Neuronal Model of Parkinson's Disease

Fibril growth and seeding capacity play key roles in α-synuclein-mediated apoptotic cell death

High aspect ratio nanofibril materials

Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease

The centriolar protein CPAP G-box: an amyloid fibril in a single domain

Infrared nanospectroscopy characterization of oligomeric and fibrillar aggregates during amyloid formation