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The chemoselective three-phase hydrogenation of an Ombrabulinintermediate based on a nitro-stilbene framework was used as a case study for the formation of the primary amine without affecting the double bond. Two catalysts were tested: Pt nanoparticles sup ...
Elsevier Science Sa2017
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Concentrations measured during the course of reactions are typically corrupted by random noise. Data reconciliation techniques improve the accuracy of measurements by using redundancies in the material and energy balances expressed as relationships between ...
Production of optically pure products can be based on simple unselective synthesis of racemic mixtures combined with a subsequent separation of the enantiomers; however, this approach suffers from a 50% yield limitation which can be overcome by racemizatio ...
Due to the limited efficiency of conventional biological treatment, innovative solutions are being explored to improve the removal of trace organic chemicals in wastewater. Controlling biomass exposure to growth substrate represents an appealing option for ...
Orbitally shaken bioreactors (OSRs) support the suspension cultivation of animal cells at volumetric scales up to 200 L and are a potential alternative to stirred-tank bioreactors (STRs) due to their rapid and homogeneous mixing and high oxygen transfer ra ...
The identification of kinetic models for multiphase reaction systems is complex due to the simultaneous effect of chemical reactions and mass transfers. The extentbased incremental approach simplifies the modeling task by transforming the reaction system i ...
American Chemical Society2016
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Abstract of the conference paper The kinetic identification of chemical reaction systems often represents a time-consuming and complex task. This contribution presents an approach that uses rate estimation and feedback linearization to implement ...
Elsevier2015
The concept of variant and invariant states has been developed to decouple the various dynamic effects in reaction systems. The aim of the project is to explore the applications of this concept to control of reaction systems. The concept of reaction varian ...
2015
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A simple and general procedure has been developed to determine the thermal behaviour of a reactor based on heat balance, PID temperature control, and jacket behaviour. Using only temperature heating/cooling ramps followed by isothermal stages, such a proce ...
Wiley-Blackwell2017
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Experimental assessment or prediction of plant steady state is important for many applications in the area of modeling and operation of continuous processes. For example, the iterative implementation of static real-time optimization requires reaching stead ...