Aspermia is the complete lack of semen with ejaculation (not to be confused with azoospermia, the lack of sperm cells in the semen). It is associated with infertility.
One of the causes of aspermia is retrograde ejaculation, because of that the sperm is kept into the bladder and the final ejaculate is 0 mL. It can be brought on by excessive drug use, or as a result of prostate surgery. It can also be caused by alpha blockers such as tamsulosin and silodosin.
Another cause of aspermia is ejaculatory duct obstruction, which may result in a complete lack or a very low-concentration of semen (oligospermia), in which the semen contains only the secretion of accessory prostate glands downstream to the orifice of the ejaculatory ducts.
Aspermia can be caused by androgen deficiency. This can be the result of absence of puberty, in which the prostate gland and seminal vesicles (which are the main sources of semen) remain small due to lack of androgen exposure and do not produce seminal fluid, or of treatment for prostate cancer, such as maximal androgen blockade.
It is important not to confuse aspermia with azoospermia, which is a pathological condition in which ejaculation occurs but no sperm are found in the semen. In aspermia, spermatozoa are produced, but they cannot be ejaculated. The sperm remain in the urinary bladder, where they die due to the acidic environment of the urine. To prevent this death of the sperm, oral bicarbonate is administered for a while, which bases the urine, so that the sperm are no longer exposed to such a hostile environment and could be collected from the urine to be used in IVF.
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Ejaculatory duct obstruction (EDO) is a pathological condition which is characterized by the obstruction of one or both ejaculatory ducts. Thus, the efflux of (most constituents of) semen is not possible. It can be congenital or acquired. It is a cause of male infertility and/or pelvic pain. Ejaculatory duct obstruction must not be confused with an obstruction of the vas deferens. If both ejaculatory ducts are completely obstructed, affected men will demonstrate male infertility due to aspermia/azoospermia.
Male infertility refers to a sexually mature male's inability to impregnate a fertile female. In humans it accounts for 40–50% of infertility. It affects approximately 7% of all men. Male infertility is commonly due to deficiencies in the semen, and semen quality is used as a surrogate measure of male fecundity. More recently, advance sperm analyses that examine intracellular sperm components are being developed.
Ejaculation is the discharge of semen (the ejaculate; normally containing sperm) from the male reproductive tract as a result of an orgasm. It is the final stage and natural objective of male sexual stimulation, and an essential component of natural conception. Ejaculation can occur spontaneously during sleep, and is a normal part of human sexual development (a nocturnal emission or "wet dream"). In rare cases, ejaculation occurs because of prostatic disease. Anejaculation is the condition of being unable to ejaculate.
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