Publications related to Synonymous substitution

Optimization of elastic wave propagation in a reconfigurable medium by genetic algorithms with adaptive mutation probability

Romain Christophe Rémy Fleury, Janez Rus

We introduce a reconfigurable medium for the manipulation of elastic propagation properties of Lamb waves. It is based on a shape memory polymer (SMP) with temperature-dependent Young's modulus. Waves are excited by a laser pulse and detected by a laser vi ...

IOP Publishing Ltd2023

Cgas super-enzymes for cancer immunotherapy

Andrea Ablasser, Natasha Ella Samson

The present invention relates to anti-tumor lymphocytes, and a variant cyclic GMP-AMP synthase (cGAS) carrying an amino acid substitution of one or both arginines at amino acid positions 255 and 236 and/or an amino acid substitution of one or both lysines ...

2023

Resist or perish: Fate of a microbial population subjected to a periodic presence of antimicrobial

Anne-Florence Raphaëlle Bitbol, Loïc Marrec

The evolution of antimicrobial resistance can be strongly affected by variations of antimicrobial concentration. Here, we study the impact of periodic alternations of absence and presence of antimicrobial on resistance evolution in a microbial population, ...

2020

Adapt or Perish: Evolutionary Rescue in a Gradually Deteriorating Environment

Anne-Florence Raphaëlle Bitbol, Loïc Marrec

We investigate the evolutionary rescue of a microbial population in a gradually deteriorating environment, through a combination of analytical calculations and stochastic simulations. We consider a population destined for extinction in the absence of mutan ...

2020

Robust landscapes of ribosome dwell times and aminoacyl-tRNAs in response to nutrient stress in liver

Felix Naef, Cédric Gobet, Frédéric Bruno Martin Gachon, Benjamin Dieter Weger, Nagammal Neelagandan

Translation depends on messenger RNA (mRNA)-specific initiation, elongation, and termination rates. While translation elongation is well studied in bacteria and yeast, less is known in higher eukaryotes. Here we combined ribosome and transfer RNA (tRNA) pr ...

2020

Method for Identification of Threonine Isoforms in Peptides by Ultraviolet Photofragmentation of Cold Ions

Vladimir Kopysov, Aleksandr Pereverzev, Elizaveta Solovyeva

Identification of isomeric amino acid residues in peptides and proteins is challenging but often highly desired in proteomics. One of the practically important cases that require isomeric assignments is that associated with single-nucleotide polymorphism s ...

AMER CHEMICAL SOC2019

Tissue- and sex-specific small RNAomes reveal sex differences in response to the environment

Pierre Gönczy, Alexandra Bezler, Frédéric Schütz, Laurent Keller, Raffaella Conconi

RNA interference (RNAi) related pathways are essential for germline development and fertility in metazoa and can contribute to inter- and trans-generational inheritance. In the nematode Caenorhabditis elegans, environmental double-stranded RNA provided by ...

PUBLIC LIBRARY SCIENCE2019

The fitness landscape of the codon space across environments

Jeffrey David Jensen, Claudia Bank, Sebastian Matuszewski

Fitness landscapes map the relationship between genotypes and fitness. However, most fitness landscape studies ignore the genetic architecture imposed by the codon table and thereby neglect the potential role of synonymous mutations. To quantify the fitnes ...

NATURE PUBLISHING GROUP2018

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Synonymous substitution

Optimization of elastic wave propagation in a reconfigurable medium by genetic algorithms with adaptive mutation probability

Cgas super-enzymes for cancer immunotherapy

Resist or perish: Fate of a microbial population subjected to a periodic presence of antimicrobial

Adapt or Perish: Evolutionary Rescue in a Gradually Deteriorating Environment

Robust landscapes of ribosome dwell times and aminoacyl-tRNAs in response to nutrient stress in liver

Method for Identification of Threonine Isoforms in Peptides by Ultraviolet Photofragmentation of Cold Ions

Feature Learning of Virus Genome Evolution With the Nucleotide Skip-Gram Neural Network

Tissue- and sex-specific small RNAomes reveal sex differences in response to the environment

The fitness landscape of the codon space across environments

Circadian clock- and feeding-dependent regulation of translation initiation and elongation in the liver

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Chat with Graph Search

Optimization of elastic wave propagation in a reconfigurable medium by genetic algorithms with adaptive mutation probability

Robust landscapes of ribosome dwell times and aminoacyl-tRNAs in response to nutrient stress in liver

Method for Identification of Threonine Isoforms in Peptides by Ultraviolet Photofragmentation of Cold Ions

Resist or perish: Fate of a microbial population subjected to a periodic presence of antimicrobial

Cgas super-enzymes for cancer immunotherapy

Adapt or Perish: Evolutionary Rescue in a Gradually Deteriorating Environment

Feature Learning of Virus Genome Evolution With the Nucleotide Skip-Gram Neural Network

Circadian clock- and feeding-dependent regulation of translation initiation and elongation in the liver

Tissue- and sex-specific small RNAomes reveal sex differences in response to the environment

The fitness landscape of the codon space across environments