Concept

Lissencephaly

Related publications (32)

Decreased Lin7b expression in layer 5 pyramidal neurons may contribute to impaired corticostriatal connectivity in huntington disease

Motor dysfunction, cognitive impairment, and regional cortical atrophy indicate cerebral cortical involvement in Huntington disease (HD). To address the hypothesis that abnormal corticostriatal connectivity arises from polyglutamine-related alterations in ...

Lippincott, Williams & Wilkins2010

Whole-brain structural connectivity in patients with focal epilepsy studied with MRI diffusion spectrum imaging (DSI)

Jean-Philippe Thiran, Tobias Kober, Reto Meuli, Leila Cammoun, Alia Lemkaddem, François Lazeyras, Christoph Michel

In patients with focal epilepsy, diffusion MRI often reveals structural changes extending beyond visible lesions or show structural abnormalities even when the clinical scans are normal. MR Tractography based on diffusion tensor imaging allows non-invasive ...

2010

Interaction between Reelin and Notch signaling regulates neuronal migration in the cerebral cortex

Freddy Radtke

Neuronal migration is a fundamental component of brain development whose failure is associated with various neurological and psychiatric disorders. Reelin is essential for the stereotypical inside-out sequential lamination of the neocortex, but the molecul ...

2008

Molecular heterogeneity of the ganglionic eminence and its relationship to the birth of neocortical interneurons

Susan Willi Monnerat

Neocortical function and malfunction depends critically on a spectrum of inhibitory interneurons. To gain novel insight in normal brain function and mechanisms leading to diseases, such as epilepsy or schizophrenia, the knowledge about the specific functio ...

EPFL2007

Coupling of cortical dynein and Galpha proteins mediates spindle positioning in Caenorhabditis elegans

Pierre Gönczy

Despite being essential for spatial cell division control, the mechanisms governing spindle positioning remain incompletely understood. In the Caenorhabditis elegans one-cell stage embryo, the spindle becomes asymmetrically positioned during anaphase throu ...

2007

Abnormal patterns of cortical gyrification in velo-cardio-facial syndrome (deletion 22q11.2): an MRI study

Marie Schaer, François Lazeyras

Velo-cardio-facial syndrome (VCFS), also known as 22q11.2 deletion syndrome, is a common genetic condition associated with increased risk for developing schizophrenia. Given that cortical malformations play an integral role in the pattern of neuroanatomica ...

2006

NEOBASE: databasing the neocortical microcircuit

Henry Markram

Mammals adapt to a rapidly changing world because of the sophisticated perceptual and cognitive function enabled by the neocortex. The neocortex, which has expanded to constitute nearly 80% of the human brain seems to have arisen from repeated duplication ...

2005

Anatomical, physiological and molecular properties of Martinotti cells in the somatosensory cortex of the juvenile rat

Henry Markram, Gilad Silberberg, Yi Wang

Whole-cell patch-clamp recordings followed by histochemical staining and single-cell RT-PCR were obtained from 180 Martinotti interneurones located in layers II to VI of the somatosensory cortex of Wistar rats (P13-P16) in order to examine their anatomical ...

2004

Correlation maps allow neuronal electrical properties to be predicted from single-cell gene expression profiles in rat neocortex

Henry Markram

The computational power of the neocortex arises from interactions of multiple neurons, which display a wide range of electrical properties. The gene expression profiles underlying this phenotypic diversity are unknown. To explore this relationship, we comb ...

Oxford University Press2004

[Mechanisms of cell division: lessons from a nematode]

Pierre Gönczy

The mechanisms orchestrating spatial cell division control remain poorly understood. In animal cells, the position of the mitotic spindle dictates cleavage furrow placement, and thus plays a key role in governing spatial relationships between resulting dau ...

2003

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