Concept
Cholinesterase inhibitor
Related publications (13)
Tracking spatiotemporal localisation and interactions of the innate immune sensor STING
Innate immunity, the very first line of defence of our cells, relies on the detection of universal pathogen- or danger-associated signals to launch an inflammatory response. A crucial part of our innate immune system is based on the recognition of out-of-c ...
EPFL2023Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism
Henning Paul-Julius Stahlberg, Dongchun Ni
ABCG2 is a multidrug transporter that affects drug pharmacokinetics and contributes to multidrug resistance of cancer cells. In previously reported structures, the reaction cycle was halted by the absence of substrates or ATP, mutation of catalytic residue ...
NATURE RESEARCH2021Acidic tumor microenvironment abrogates the efficacy of mTORC1 inhibitors
Background: Blocking the mechanistic target of rapamycin complex-1 (mTORC1) with chemical inhibitors such as rapamycin has shown limited clinical efficacy in cancer. The tumor microenvironment is characterized by an acidic pH which interferes with cancer t ...
Biomed Central Ltd20161,2,3-Triazoles as inhibitors of indoleamine 2,3-dioxygenase 2 (IDO2)
Pierre Vogel, George Coukos, Somi Reddy Majjigapu, Olivier Michielin
Indoleamine 2,3-dioxygenase 2 (IDO2) is a potential therapeutic target for the treatment of diseases that involve immune escape such as cancer. In contrast to IDO1, only a very limited number of inhibitors have been described for IDO2 due to inherent diffi ...
Pergamon-Elsevier Science Ltd2016