Publications related to Gene mapping

On the (un) predictability of a large intragenic fitness landscape

Jeffrey David Jensen, Claudia Bank, Sebastian Matuszewski

The study of fitness landscapes, which aims at mapping genotypes to fitness, is receiving ever-increasing attention. Novel experimental approaches combined with next-generation sequencing (NGS) methods enable accurate and extensive studies of the fitness e ...

Natl Acad Sciences2016

Abrogation of HMX1 Function Causes Rare Oculoauricular Syndrome Associated With Congenital Cataract, Anterior Segment Dysgenesis, and Retinal Dystrophy

PURPOSE. To define the phenotypic manifestation, confirm the genetic basis, and delineate the pathogenic mechanisms underlying an oculoauricular syndrome (OAS). METHODS. Two individuals from a consanguineous family underwent comprehensive clinical phenotyp ...

Assoc Research Vision Ophthalmology Inc2015

Limits and patterns of cytomegalovirus genomic diversity in humans

Jeffrey David Jensen, Cornelia Pokalyuk

Human cytomegalovirus (HCMV) exhibits surprisingly high genomic diversity during natural infection although little is known about the limits or patterns of HCMV diversity among humans. To address this deficiency, we analyzed genomic diversity among congeni ...

Natl Acad Sciences2015

Meta-analysis of incomplete microarray studies

Anthony Christopher Davison, Darlene Goldstein

Meta-analysis of microarray studies to produce an overall gene list is relatively straightforward when complete data are available. When some studies lack information, for example, having only a ranked list of genes instead of complete primary data, it is ...

Oxford University Press2015

Structure of silent transcription intervals and noise characteristics of mammalian genes

Felix Naef, Benjamin Zoller, Damien Lionel Nicolas

Mammalian transcription occurs stochastically in short bursts interspersed by silent intervals showing a refractory period. However, the underlying processes and consequences on fluctuations in gene products are poorly understood. Here, we use single allel ...

Nature / European Molecular Biology Organization2015

Systems Biology Approaches for Inflammatory Bowel Disease: Emphasis on Gut Microbial Metabolism

Martin Kussmann, Sofia Moco

Although the prevalence of main idiopathic forms of inflammatory bowel disease (IBD) has risen considerably over the last decades, their clinical features do not allow accurate prediction of prognosis, likelihood of disease progression, or response to spec ...

Lippincott Williams & Wilkins2014

On Detecting Incomplete Soft or Hard Selective Sweeps Using Haplotype Structure

Anna Ferrer Admetlla

We present a new haplotype-based statistic (nS(L)) for detecting both soft and hard sweeps in population genomic data from a single population. We compare our new method with classic single-population haplotype and site frequency spectrum (SFS)-based metho ...

Oxford Univ Press2014

Extending the Schizosaccharomyces pombe Molecular Genetic Toolbox

Viesturs Simanis, Andrea Krapp

Targeted alteration of the genome lies at the heart of the exploitation of S. pombe as a model system. The rate of analysis is often determined by the efficiency with which a target locus can be manipulated. For most loci this is not a problem, however for ...

Public Library of Science2014

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Gene mapping

On the (un) predictability of a large intragenic fitness landscape

Isoform switching of steroid receptor co-activator-1 attenuates glucocorticoid-induced anxiogenic amygdala CRH expression

Abrogation of HMX1 Function Causes Rare Oculoauricular Syndrome Associated With Congenital Cataract, Anterior Segment Dysgenesis, and Retinal Dystrophy

Quantitative single-cell analysis of S. cerevisiae using a microfluidic live-cell imaging platform

Limits and patterns of cytomegalovirus genomic diversity in humans

Meta-analysis of incomplete microarray studies

Structure of silent transcription intervals and noise characteristics of mammalian genes

Systems Biology Approaches for Inflammatory Bowel Disease: Emphasis on Gut Microbial Metabolism

On Detecting Incomplete Soft or Hard Selective Sweeps Using Haplotype Structure

Extending the Schizosaccharomyces pombe Molecular Genetic Toolbox

Graph Chatbot

Chat with Graph Search

Abrogation of HMX1 Function Causes Rare Oculoauricular Syndrome Associated With Congenital Cataract, Anterior Segment Dysgenesis, and Retinal Dystrophy

Isoform switching of steroid receptor co-activator-1 attenuates glucocorticoid-induced anxiogenic amygdala CRH expression

Structure of silent transcription intervals and noise characteristics of mammalian genes

On the (un) predictability of a large intragenic fitness landscape

Quantitative single-cell analysis of S. cerevisiae using a microfluidic live-cell imaging platform

On Detecting Incomplete Soft or Hard Selective Sweeps Using Haplotype Structure

Limits and patterns of cytomegalovirus genomic diversity in humans

Extending the Schizosaccharomyces pombe Molecular Genetic Toolbox

Meta-analysis of incomplete microarray studies

Systems Biology Approaches for Inflammatory Bowel Disease: Emphasis on Gut Microbial Metabolism