Concept

Neutralizing antibody

Related publications (134)

Specific recognition of the viral protein UL18 by CD85j/LIR-1/ILT2 on CD8+ T cells mediates the non-MHC-restricted lysis of human cytomegalovirus-infected cells

Immune evasion mechanisms of human CMV are known; however, the immune control of infection remains poorly elucidated. We show that interaction between the viral protein UL18 on infected cells and the invariant receptor CD85j/LIR-1/ILT2 expressed on CTL is ...

2004

Freezing immunoglobulins to see them move

Paolo De Los Rios, Francesco Piazza

The issue of protein dynamics and its implications in the biological function of proteins are arousing greater and greater interest in different fields of molecular biology. In cryo-electron tomography experiments one may take several snapshots of a given ...

National Academy of Sciences2004

Hide, shield and strike back: how HIV-infected cells avoid immune eradication

Didier Trono

Viruses that induce chronic infections can evade immune responses. HIV is a prototype of this class of pathogen. Not only does it mutate rapidly and make its surface components difficult to access by neutralizing antibodies, but it also creates cellular hi ...

2003

Presence of Gal-alpha1,3Gal epitope on xenogeneic lines: implications for cellular gene therapy based on the encapsulation technology

Patrick Aebischer

Exposure to human serum induces the lysis of xenogeneic cells through natural antibodies and complement activation. The carbohydrate Galactose-alpha1,3-Galactose (Gal-alpha1,3-Gal) epitope, has been shown to be the principal antigenic determinant on target ...

2003

The generation of monoclonal antibodies against human peroxisome proliferator-activated receptors (PPARs)

Johan Auwerx

Monoclonal antibodies (Mabs) are valuable reagents for the purification, characterization and immunolocalization of proteins.In this study, we raised Mabs against human peroxisome proliferator-activated receptors (PPARs) using baculovirus particles display ...

2002

100-liter transient transfection

Florian Maria Wurm, Madiha Derouazi, Martin Jordan, Philippe Pierre Girard

This is the first report of two successful 100 l scale transienttransfections in a standard stirred bioreactor. More than half a gram of a monoclonal antibody (IgG) were produced in less than 10 days using a technology called large-scale transient gene exp ...

2002

Balancing GFP reporter plasmid quantity in large-scale transient transfections for recombinant anti-human Rhesus-D IgG1 synthesis

Horst Vogel, Florian Maria Wurm, Horst Pick

Using transient expression, high amounts (>20 mg/mL) of secreted anti-human Rhesus-D IgG1 were produced in a suspension-adapted HEK293 EBNA cell line (Meissner et al., Biotechnol Bioeng 75: 197-203, 2001). Time of harvest was 3 days after transfection. For ...

2002

Transepithelial transport of HIV-1 by M cells is receptor-mediated

Didier Trono, Alexandre Harari

Human colon carcinoma Caco-2 cell monolayers undergo conversion into cells that share morphological and functional features of M cells when allowed to interact with B lymphocytes. A lymphotropic (X4) HIV-1 strain crosses M cell monolayers and infects under ...

2002

Towards the generation of artificial O6-alkylguanine-DNA alkyltransferases: In vitro selection of antibodies with reactive cysteine residues

Kai Johnsson

A stepwise approach to the development of artificial O6-alkylguanine-DNA alkyltransferases (AGTs) and its application to the in vitro selection of antibodies with highly reactive cysteine residues are described. As a result of low reactivity of O6-alkylate ...

2002

Aerolysin from Aeromonas hydrophila and related toxins

Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami

Aeromonads are ubiquitous gram-negative bacteria found in aqueous environments. Some members of the genus are pathogenic for fish, reptiles and cows. In humans, Aeromonas infection is mainly associated with grastrointestinal diseases, but in immuno-comprom ...

2001

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