Concept
Neutralizing antibody
Related publications (134)
Antibodies Trap Tissue Migrating Helminth Larvae and Prevent Tissue Damage by Driving IL-4Rα-Independent Alternative Differentiation of Macrophages
Arne Seitz, Romain Guiet, Nicola Harris, Alessandra Piersigilli, Beatrice Volpe, Julia Esser-von Bieren, Ilaria Mosconi, Fei Chen
Approximately one-third of the world's population suffers from chronic helminth infections with no effective vaccines currently available. Antibodies and alternatively activated macrophages (AAM) form crucial components of protective immunity against chall ...
Public Library of Science2013Characterization of Three Amino-Functionalized Surfaces and Evaluation of Antibody Immobilization for the Multiplex Detection of Tumor Markers Involved in Colorectal Cancer
Vincent Laporte, Nicolas Xanthopoulos
Antibody microarrays are powerful and high-throughput tools for screening and identifying tumor markers from small sample volumes of only a few microliters. Optimization of surface chemistry and spotting conditions are crucial parameters to enhance antibod ...
Amer Chemical Soc2013TLR4- and TRIF-dependent stimulation of B lymphocytes by peptide liposomes enables T cell-independent isotype switch in mice
Pedro Miguel Nunes Pereira de Almeida Reis, Andrea Pfeifer, Marija Vukicevic, Andreas Muhs, Valérie Gafner, Anna Lucia Buccarello
Immunoglobulin class switching from IgM to IgG in response to peptides is generally T cell-dependent and vaccination in T cell-deficient individuals is inefficient. We show that a vaccine consisting of a dense array of peptides on liposomes induced peptide ...
Amer Soc Hematology2013A novel encapsulation device for peripheral implantation of antibody-secreting cells
Alzheimer’s disease (AD) is the most prevalent form of dementia in the elderly. As populations are aging in most parts of the world, the number of people with Alzheimer’s disease is expected to dramatically increase. This devastating neurodegenerative diso ...
EPFL2013Lymphatic vasculature mediates macrophage reverse cholesterol transport in mice
Reverse cholesterol transport (RCT) refers to the mobilization of cholesterol on HDL particles (HDL-C) from extravascular tissues to plasma, ultimately for fecal excretion. Little is known about how HDL-C leaves peripheral tissues to reach plasma. We first ...
American Society for Clinical Investigation2013Anti-angiogenic treatment for exudative age-related macular degeneration: new strategies are underway
Exudative age-related macular degeneration (AMD) is the leading cause of blindness in elderly people in the western world. Recent developments in the field yielded vascular endothelial growth factor (VEGF) targeted strategies that caused a revolution in th ...
2012Total serum IgE quantification by microfluidic ELISA using magnetic beads
Hubert Girault, Anne-Laure Gassner
The present work reports on the quantification of total IgE in human serum using a microanalytical device whose fluidics is driven by gravity and capillary forces only. Thanks to the eight parallel microchannels in each microchip, calibration and sample an ...
Springer Verlag2012Therapeutic antibodies targeting app-c99
Lorène Aeschbach, Patrick Fraering, Tristan Bolmont, Jemila Houacine
The present invention relates to an isolated and/or purified antibody, antibody fragment or derivative thereof able to block the gamma-secretase-dependent processing of the amyloid precursor protein (APP) and to pharmaceutical compositions containing said ...
2012Selective neutralization of APP-C99 with monoclonal antibodies reduces the production of Alzheimer's Aβ peptides
Lorène Aeschbach, Patrick Fraering, Tristan Bolmont, Jemila Houacine
The toxic amyloid-β (Aβ) peptides involved in Alzheimer's disease (AD) are produced after processing of the amyloid precursor protein-C-terminal fragment APP-C99 by γ-secretase. Thus, major therapeutic efforts have been focused on inhibiting the activity o ...
Elsevier Science Inc2012System and Method For In Vivo Delivery of Antibodies and Fragments Thereof
Patrick Aebischer, Maurizio Molinari, Nicolas Bouche
The present invention is directed to devices and methods for in situ delivering an antibody or a fragment thereof to a host. In particular, the invention relates to devices and methods for in situ delivering an antibody or a fragment thereof to patient suf ...
2011