Concept

Area under the curve (pharmacokinetics)

Related publications (32)

Dynamics of antibiotics concentrations in the environment at different time scales

David Andrew Barry, Luca Rossi, Sylvain Coutu, Vera Wyrsch

The aim of this study was to assess the most relevant time scales of antibiotics concentration variations at the sewage treatment plant (STP) inlet and to create a model for the simulation of short-term concentration variations. During one year six antibio ...

2012

Proton and phosphorus magnetic resonance spectroscopy of a mouse model of Alzheimer's disease

Rolf Gruetter, Patrick Aebischer, Bernard Schneider, Cristina Ramona Cudalbu, Hongxia Lei, Sharon Janssens, Lili Sun-Reimer

The development of new diagnostic criteria for Alzheimer's disease (AD) requires new in vivo markers reflecting early pathological changes in the brain of patients. Magnetic resonance (MR) spectroscopy has been shown to provide useful information about the ...

Ios Press2012

Example-based Support Vector Machine for Drug Concentration Analysis

Giovanni De Micheli, Wenqi You Dubout

Machine learning has been largely applied to ana- lyze data in various domains, but it is still new to personalized medicine, especially dose individualization. In this paper, we focus on the prediction of drug concentrations using Support Vector Machines ...

Ieee Service Center, 445 Hoes Lane, Po Box 1331, Piscataway, Nj 08855-1331 Usa2011

ERBIN is a new SARA-interacting protein: Competition between SARA and SMAD2 and SMAD3 for binding to ERBIN

Georgios Sflomos

SARA, an early endosomal protein, plays a key role in TGFβ signalling, as it presents SMAD2 and SMAD3 for phosphorylation by the activated TGFβ receptors. Here, we show that ERBIN is a new SARA-interacting protein that can be recruited by SARA to early end ...

Company of Biologists2011

Effect of Humic Substance Photoalteration on Lead Bioavailability to Freshwater Microalgae

Pascal Miéville, Julian Spierings

The present study provides results on the influence of humic substance (HS) photoalteration on lead availability to the freshwater microalga Chlorella kesslerii. The evolution of the free lead-ion concentrations measured by the ion exchange technique [Pb]( ...

2011

DCE-MRI data analysis for cancer area classification

Alessandro Daducci

OBJECTIVES: The paper aims at improving the support of medical researchers in the context of in-vivo cancer imaging. Morphological and functional parameters obtained by dynamic contrast-enhanced MRI (DCE-MRI) techniques are analyzed, which aim at investiga ...

Schattauer2009

In vivo MRI assessment of a novel GdIII-based contrast agent designed for high magnetic field applications

André Merbach, Lothar Helm, Eva Jakab Toth, Joao Bruno Livramento Fig.

Gd3L is a trinuclear Gd3R complex of intermediate size, designed for contrast agent applications in high field magnetic resonance imaging (H12L is based on a trimethylbenzene core bearing three methylene-diethylenetriamine-N,N,N00,N00-tetraacetate moieties ...

2008

Clinical fluorescence spectroscopy and imaging for the detection of early carcinoma by autofluorescence bronchoscopy and the study of the protoporphyrin IX pharmacokinetics in the endometrium

Tanja Gabrecht

The aim of this thesis is to optimise and gain fundamental information on two applications of photomedicine using fluorescence imaging and spectrofluorometry: (1) the detection of early bronchial cancer by autofluorescence imaging and (2) the endometrial a ...

EPFL2006

Population pharmacokinetics and effects of efavirenz in patients with human immunodeficiency virus infection

Jacques Fellay, Amalio Telenti, Thierry Buclin

The reverse transcriptase inhibitor efavirenz is currently used at a fixed dose of 600 mg/d. However, dosage individualization based on plasma concentration monitoring might be indicated. This study aimed to assess the efavirenz pharmacokinetic profile and ...

Elsevier2003

Responses of Mycobacterium sp LB501T to the low bioavailability of solid anthracene

Several recent reports have indicated that some bacteria may have adapted to the low bioavailability of hydrophobic environmental chemicals and that generalizations about the bioavailability of compounds such as polycyclic aromatic hydrocarbons (PAHs) may ...

Springer Verlag2002

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