Concept

Clostridium novyi

Summary
Clostridium novyi (oedematiens) a Gram-positive, endospore- forming, obligate anaerobic bacteria of the class Clostridia. It is ubiquitous, being found in the soil and faeces. It is pathogenic, causing a wide variety of diseases in man and animals. Growth in culture proceeds through 3 stages: Initial growth wherein no toxin is produced; vigorous growth wherein toxin is produced; and spore formation wherein endospores are formed and toxin production decreases. It is suggested that type C may be type B that forms spores more readily so does not go through the toxin-production stage. Isolating and identifying C novyi is difficult due to its extreme anaerobic nature. Commercial kits may not be adequate. It is also fastidious and difficult to culture, requiring the presence of thiols. Taxonomy Clostridium novyi is considered to be made up from three clades, labelled A, B and C, distinguished by the range of toxins they produce. While strains of type C were not linked to disease
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