Concept

Liquid chromatography–mass spectrometry

Related publications (496)

CO2 hydrogenation on a metal hydride surface

The catalytic hydrogenation of CO 2 at the surface of a metal hydride and the corresponding surface segregation were investigated. The surface processes on Mg 2NiH 4 were analyzed by in situ X-ray photoelectron spectroscopy (XPS) combined with thermal deso ...

2012

Fragmentation methods on the balance: unambiguous top–down mass spectrometric characterization of oxaliplatin–ubiquitin binding sites

Paul Joseph Dyson, Yury Tsybin, Christian Hartinger

The interaction between oxaliplatin and the model protein ubiquitin (Ub) was investigated in a top-down approach by means of high-resolution electrospray ionization mass spectrometry (ESI-MS) using diverse tandem mass spectrometric (MS/MS) techniques, incl ...

Springer-Verlag2012

Novel Approaches in Tandem Mass Spectrometry for Peptide and Protein Structure Analysis

Aleksey Vorobyev

Results of the mechanistic studies of free-electron based fragmentation methods addressing peptide and protein structure analysis with mass spectrometry (MS), electron capture dissociation (ECD) and electron ionization dissociation (EID), are presented. Se ...

EPFL2012

Combination of Gas-Phase Fractionation and MS3 Acquisition Modes for Relative Protein Quantification with Isobaric Tagging

Loïc Dayon, Martin Kussmann

Relative quantification of peptides and proteins with isobaric tags such as iTRAQ or TMT is commonly used in comparative quantitative proteomics based on tandem mass spectrometry (MS/MS). Nonetheless, isobaric tagging inherently suffers from the cofragment ...

Amer Chemical Soc2012

Delivery of floxuridine derivatives to cancer cells by water-soluble organometallic-cages

Paul Joseph Dyson, Olivier Pierre Zava

The self-assembly of 2,4,6-tris(pyridin-4-yl)-1,3,5-triazine (tpt) triangular panels with p-cymene (pPr(i)C(6)H(4)Me) ruthenium building blocks and 2,5-dioxydo-1,4-benzoquinonato (dobq) or 5,8-dioxydo-1,4-naphthoquinonato (donq) bridges, in the presence of ...

American Chemical Society2012

Filter Diagonalization Method-Based Mass Spectrometry for Molecular and Macromolecular Structure Analysis

Yury Tsybin, Anton Kozhinov

Molecular and macromolecular structure analysis by high resolution and accurate mass spectrometry (MS) is indispensable for a number of fundamental and applied research areas, including health and energy domains. Comprehensive structure analysis of molecul ...

2012

Barium Ions and Helium Nanodroplets: Solvation and Desolvation

Marcel Drabbels, Xiaohang Zhang

The solvation of Ba+ ions created by the photoionization of barium atoms located on the surface of helium nanodroplets has been investigated. The excitation spectra corresponding to the 6p 2P1/2

American Institute of Physics2012

Observation of ion coalescence in Orbitrap Fourier transform mass spectrometry

Yury Tsybin, Luca Fornelli

RATIONALE Similar to other mass spectrometric technologies based on ion trapping in a spatially restricted area, the performance of Orbitrap Fourier transform mass spectrometry (FTMS) is affected by the interaction between the trapped ion clouds. One of th ...

Wiley-Blackwell2012

Transfer Kinetics of Polar Organic Compounds over Polyethersulfone Membranes in the Passive Samplers Pocis and Chemcatcher

Juliane Hollender

Passive samplers for polar organic compounds often use a polyethersulfone (PES) membrane to retain the particulate sorbent material (e.g., in a POCIS; polar organic chemical integrative sampler) or to reduce the sampling rate and thus extend the kinetic re ...

2012

Validation of an in vitro digestive system for studying macronutrient decomposition in humans

Martinus Gijs, Guy Vergères, Flurina Schwander, Reto Portmann

The digestive process transforms nutrients and bioactive compounds contained in food to physiologically active compounds. In vitro digestion systems have proven to be powerful tools for understanding and monitoring the complex transformation processes that ...

2012

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