Pyridine

Natural sciences
Chemistry
Chemical reactions
Condensation reactions

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Divergent Synthesis of Densely Substituted Arenes and Pyridines via Cyclotrimerization Reactions of Alkynyl Triazenes

Kay Severin, Nicolai Cramer, Carl Thomas Bormann, Florian Gérald Abela, Jin Fay Tan, Frederick Mark Chadwick

Densely substituted fused aromatic triazenes can be prepared by [2 + 2 + 2] cyclotrimerization reactions of 1-alkynyl triazenes. The Cp*Ru-catalyzed cyclization proceeds well with both simple alkynyl triazenes and tethered 1-diynyl triazenes. Attractively, ...

2019

Proteomics and Beyond: Cell Decision-Making Shaped by Reactive Electrophiles

Yimon Aye, Xuyu Liu

Revolutionary proteomic strategies have enabled rapid profiling of the cellular targets of electrophilic small molecules. However, precise means to directly interrogate how these individual electrophilic modifications at low occupancy functionally reshape ...

2019

A Short Synthesis of the 2-Bromo-N,9-dimethyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-b]indol-6-amine Building Block

Andrea Pfeifer, Andreas Muhs

A concise synthesis of pharmaceutically useful (R)-tert-butyl N-(2-bromo-9-methyl-6,7,8,9-tetrahydro-5H-pyrido [2,3-b ] indol-6-yl) -N-methylcarbamate building block 11 is described. The racemic intermediate 17 was prepared in a single step from 2-bromo-6- ...

AMER CHEMICAL SOC2019

A Cobalt-Iron Double-Atom Catalyst for the Oxygen Evolution Reaction

Xile Hu, Duncan Thomas Lindsay Alexander, Lichen Bai

Single-atom catalysts exhibit well-defined active sites and potentially maximum atomic efficiency. However, they are unsuitable for reactions that benefit from bimetallic promotion such as the oxygen evolution reaction (OER) in an alkaline medium. Here we ...

2019

Pyridination of hole transporting material in perovskite solar cells questions the long-term stability

Mohammad Khaja Nazeeruddin, Natalia Gasilova, Sanghyun Paek, Kasparas Rakstys

In this work, for the first time, reactive radical-cation species present in hole-transporting materials were shown to react with tert-butylpyridine additive, routinely used in hole transporting layer composition. As a result, new pyridinated products were ...

Royal Society of Chemistry2018

Pyridyl- and Picolinic Acid Substituted Zinc(II) Phthalocyanines for Dye-Sensitized Solar Cells

Michael Graetzel, Mohammad Khaja Nazeeruddin, Jun Ho Yum, Aravind Kumar Chandiran

A series of tri-tert-butyl zinc(II) phthalocyanines (Pcs) substituted with pyridyl, carboxyl, or picolinic acid anchoring groups on the periphery were prepared. Photovoltaic (PV) studies on these dyes were carried out revealing some interesting features. I ...

Wiley-VCH Verlag2017

Ligand and Metal Based Multielectron Redox Chemistry of Cobalt Supported by Tetradentate Schiff Bases

Rosario Scopelliti, Marinella Mazzanti, Julie Renée Michelle Andrez

We have investigated the influence of bound cations on the reduction of cobalt complexes of redox active ligands and explored the reactivity of reduced species with CO2. The one electron reduction of [CoII(Rsalophen)] with alkali metals (M = Li, Na, K) lea ...

2017

Nonsteroidal Anti-inflammatory-Organometallic Anticancer Compounds

Paul Joseph Dyson, Rosario Scopelliti, Emilia Paunescu, Mylène Soudani, Sarah Mcarthur

Compounds that combine metal-based drugs with covalently linked targeted organic agents have been shown, in some instances, to exhibit superior anticancer properties compared to the individual counterparts. Within this framework, we prepared a series of or ...

Amer Chemical Soc2016

Carbon Dioxide Based N-Formylation of Amines Catalyzed by Fluoride and Hydroxide Anions

Paul Joseph Dyson, Felix Daniel Bobbink, Martin Hulla, Shoubhik Das

We described herein a simple approach for N-formylation with CO2 and hydrosilane reducing agents. Fluoride and hydroxide salts efficiently catalyzed the reaction, principally through activation of the hydrosilanes, which led to hydrosilane reactivities com ...

Wiley-VCH Verlag2016

Synthesis and structure-activity relationship of 2,6-disubstituted pyridine derivatives as inhibitors of beta-amyloid-42 aggregation

Andrea Pfeifer, Andreas Muhs, Paolo Paganetti

It is assumed that amyloid-beta aggregation is a crucial event in the pathogenesis of Alzheimer's disease. Novel 2,6-disubstituted pyridine derivatives were designed to interact with the beta-sheet conformation of A beta via donor-acceptor-donor hydrogen b ...

Pergamon-Elsevier Science Ltd2016

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Synthesis and structure-activity relationship of 2,6-disubstituted pyridine derivatives as inhibitors of beta-amyloid-42 aggregation

Andrea Pfeifer, Andreas Muhs, Paolo Paganetti

Pergamon-Elsevier Science Ltd2016

Nonsteroidal Anti-inflammatory-Organometallic Anticancer Compounds

Paul Joseph Dyson, Rosario Scopelliti, Emilia Paunescu, Mylène Soudani, Sarah Mcarthur

Amer Chemical Soc2016