Concept
Fibrin
Related publications (33)
Highly Efficient Cardiac Differentiation and Maintenance by Thrombin-Coagulated Fibrin Hydrogels Enriched with Decellularized Porcine Heart Extracellular Matrix
Philippe Renaud, Thomas Michael Braschler, Fatemeh Navaee
Biochemical and biophysical properties instruct cardiac tissue morphogenesis. Here, we are reporting on a blend of cardiac decellularized extracellular matrix (dECM) from porcine ventricular tissue and fibrinogen that is suitable for investigations employi ...
MDPI2023Vascular-targeted micelles as a specific MRI contrast agent for molecular imaging of fibrin clots and cancer cells
Anne-Sophie Chauvin, Aurélien Thomas, Vassily Vorobiev
Molecular medical imaging is intended to increase the accuracy of diagnosis, particularly in cardiovascular and cancer-related diseases, where early detection could significantly increase the treatment success rate. In this study, we present mixed micelles ...
ELSEVIER2021Method and system for analysis of organic material by auto-cathodoluminescence
Analyzing isolated collagen gel samples of a rat-tail and bovine hide, we demonstrated in situ detection of spectrally deconvoluted auto-cathodoluminescence signatures of specific molecular content with precise spatial localization over a maximum field of ...
2020Tissue Factor-Independent Coagulation Correlates with Clinical Phenotype in Factor XI Deficiency and Replacement Therapy
Christian Heinis, Vanessa Carle, Alessandro Aliotta
Background In factor XI (FXI) deficiency, bleeding cannot be predicted by routine analyses. Since FXI is involved in tissue factor (TF)-independent propagation loop of coagulation, we hypothesized that investigating the spatiotemporal separated phases of c ...
GEORG THIEME VERLAG KG2020Quantitative intrinsic auto-cathodoluminescence can resolve spectral signatures of tissue-isolated collagen extracellular matrix
Peter Frey, Jeffrey Alan Hubbell, Hans Mattias Larsson, Elif Vardar, Ganesh Vythilingam, Marcin Stefan Zielinski
By analyzing isolated collagen gel samples, we demonstrated in situ detection of spectrally deconvoluted auto-cathodoluminescence signatures of specific molecular content with precise spatial localization over a maximum field of view of 300 mu m. Correlati ...
2019Human Kunitz-type protease inhibitor engineered for enhanced matrix retention extends longevity of fibrin biomaterials
Peter Frey, Jeffrey Alan Hubbell, Hans Mattias Larsson, Priscilla Suhasna Maithili Briquez, Kristen Lorentz
Aprotinin is a broad-spectrum serine protease inhibitor used in the clinic as an anti-fibrinolytic agent in fibrin-based tissue sealants. However, upon re-exposure, some patients suffer from hypersensitivity immune reactions likely related to the bovine or ...
2017IGF-1-containing multi-layered collagen-fibrin hybrid scaffolds for bladder tissue engineering
Peter Frey, Jeffrey Alan Hubbell, Hans Mattias Larsson, Priscilla Suhasna Maithili Briquez, Elif Vardar, Kalitha Pinnagoda
Clinical success of bladder reconstructive procedures could be promoted by the availability of functional biomaterials. In this study, we have developed a multi-layered scaffold consisting of a bioactive fibrin layer laminated between two collagen sheets a ...
Elsevier Sci Ltd2016Bio-engineered collagen-fibrin scaffolds for enhancing urological tissue regeneration
Urological tissue engineering offers alternative solutions for congenital and acquired diseases of the urinary tract, which may require reconstructive surgery. It evolves to overcome complications, which might be encountered after surgery. Therefore, tissu ...
EPFL2015Long-lasting fibrin matrices ensure stable and functional angiogenesis by highly tunable, sustained delivery of recombinant VEGF(164)
Veronica Sacchi, Jeffrey Alan Hubbell, Mikaël Martino, Kristen Lorentz, Martin Ehrbar, Elena Groppa
Clinical trials of therapeutic angiogenesis by vascular endothelial growth factor (VEGF) gene delivery failed to show efficacy. Major challenges include the need to precisely control in vivo distribution of growth factor dose and duration of expression. Re ...
Natl Acad Sciences2014Engineering the growth factor microenvironment with fibronectin domains to promote wound and bone tissue healing
Jeffrey Alan Hubbell, Mikaël Martino, Federico Tortelli, Mayumi Mochizuki Martino
Although growth factors naturally exert their morphogenetic influences within the context of the extracellular matrix microenvironment, the interactions among growth factors, their receptors, and other extracellular matrix components are typically ignored ...
2011