Concept

Fibrin

Related publications (33)

Covalently conjugated VEGF-fibrin matrixes for endothelialization

Vascular endothelial growth factor (VEGF) is a key factor in endothelial cell biol. and blood vessel formation and a candidate therapeutic for the stimulation of angiogenesis-dependent tissue regeneration. The objective of this study was to confer the angi ...

2001

Development of novel growth factor fusion proteins with exogenous immobilization domains for cellularly controlled drug delivery

Jeffrey Alan Hubbell

A novel method for the delivery of growth factor proteins from fibrin matrixes was developed. Nerve growth factor (NGF) fusion proteins contg. an exogenous transglutaminase substrate at the N-terminus of the protein were made recombinantly by E. coli. The ...

2000

Enzymatic incorporation of bioactive peptides into fibrin matrices enhances neurite extension

Patrick Aebischer, Jeffrey Alan Hubbell

Fibrin plays an important role in wound healing and regeneration, and enjoys widespread use in surgery and tissue engineering. The enzymatic activity of Factor XIIIa was employed to covalently incorporate exogenous bioactive peptides within fibrin during c ...

2000

Development of fibrin derivatives for controlled release of heparin-binding growth factors

Jeffrey Alan Hubbell

The goal of this work was to develop a growth factor delivery system for use in wound healing that would provide localized release of heparin-binding growth factors in a biomimetic manner, such that release occurs primarily in response to cell-assocd. enzy ...

2000

Incorporation of heparin-binding peptides into fibrin gels enhances neurite extension: an example of designer matrices in tissue engineering

Jeffrey Alan Hubbell

The goal of this work was to improve the potential of fibrin to promote nerve regeneration by enzymatically incorporating exogenous neurite-promoting heparin-binding peptides. The effects on neurite extension of four different heparin-binding peptides, der ...

1999

Cross-linking exogenous bifunctional peptides into fibrin gels with factor XIIIa

Jeffrey Alan Hubbell

Bi-domain peptides with a factor XIIIa substrate in one domain and a bioactive peptide in another domain were covalently incorporated into fibrin gels during coagulation through the action of the transglutaminase factor XIIIa. The cross-linking characteris ...

1999

Effects of fibrin micromorphology on neurite growth from dorsal root ganglia cultured in three-dimensional fibrin gels

Jeffrey Alan Hubbell

The effect of fibrin matrix micromorphology on neurite growth was investigated by measuring the length of neurites growing in three-dimensional fibrin gels with well characterized micromorphologies. Dorsal root ganglia (DRGs) from 7-day chick embryos were ...

1998

Effects of fibinolysis on neurite growth from dorsal root ganglia cultured in two- and three-dimensional fibrin gels

Jeffrey Alan Hubbell

The mechanism of neurite penetration of three-dimensional fibrin matrices was investigated by culturing embryonic chick dorsal root ganglia (DRGs) within fibrin gels, upon fibrin gels, and upon laminin. The length of neurites within three-dimensional matri ...

1996

A new photopolymerizable blood vessel glue that seals human vessel anastomoses without augmenting thrombogenicity

Jeffrey Alan Hubbell

A new nonbiologic photopolymerizable glue, polyethyleneglycol 400 diacrylate, was studied with respect to its mechanical and biochemical interaction with human blood vessels. Using the human placental artery model, we tested the ability of polyethyleneglyc ...

1995

A slow clearing, fibrin-specific, PAI-1 resistant variant of t-PA (T103N, KHRR 296-299 AAAA)

Florian Maria Wurm

Site directed mutagenesis was used to construct a t-PA variant that contains an additional glycosylation site in the first kringle domain (T103N) combined with a tetra-alanine substitution in the protease domain (KHRR 296-299 AAAA). This combination varian ...

1993

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