Concept

Lymphocytosis

Related publications (12)

Unlocking Hidden Potential: Exploring the Complexities of Signaling in Immune Cell Activation to Optimize CAR Therapy

Chimeric antigen receptors (CARs) are synthetic, transmembrane proteins that trigger immune cell signaling following their engagement. They have been first utilized in T cells and later in natural killer (NK) cells to redirect their cytotoxicity toward a s ...

EPFL2023

Using Machine Learning to Predict Mortality for COVID-19 Patients on Day 0 in the ICU

Nahal Mansouri, Sahand Jamal Rahi

Rationale: Given the expanding number of COVID-19 cases and the potential for new waves of infection, there is an urgent need for early prediction of the severity of the disease in intensive care unit (ICU) patients to optimize treatment strategies.Objecti ...

FRONTIERS MEDIA SA2022

Regulatory T-Cells and Associated Pathways in Metastatic Renal Cell Carcinoma (mRCC) Patients Undergoing DC-Vaccination and Cytokine-Therapy

Benita Wolf

To evaluate CD4(+)CD25(+)FOXP3(+) T regulatory cells (T(REG)) and associated immune-regulatory pathways in peripheral blood lymphocytes (PBL) of metastatic renal cell carcinoma (mRCC) patients and healthy volunteers. We subsequently investigated the effect ...

Public Library of Science2012

Gene Expression Profile of Peripheral Blood Lymphocytes from Renal Cell Carcinoma Patients Treated with IL-2, Interferon-α and Dendritic Cell Vaccine

Benita Wolf

Lymphocytes are a key component of the immune system and their differentiation and function are directly influenced by cancer. We examined peripheral blood lymphocyte (PBL) gene expression as a biomarker of illness and treatment effect using the Affymetrix ...

Public Library of Science2012

Fast directed evolution of non-immunoglobulin proteins by somatic hypermutation in immune cells

Kai Johnsson, Christian Heinis

A review. New, improved phenotypes. Somatic hypermutation in immune cells can be used for the fast directed evolution of proteins other than Igs (e.g., autofluorescent proteins). The target gene is inserted into the genome of activated B lymphocytes where ...

2005

Simulating the Immune System

Thomas Schmid

The immune system has to decide on the reaction it will perform when it encounters a pathogen for the first time. The decision is based on the context in which the pathogen is presented and the signals it receives from the innate immune system. Thereafter ...

2004

Human invariant V alpha 24-J alpha Q TCR supports the development of CD1d-dependent NK1.1+ and NK1.1- T cells in transgenic mice

Friedrich Beermann

A sizable fraction of T cells expressing the NK cell marker NK1.1 (NKT cells) bear a very conserved TCR, characterized by homologous invariant (inv.) TCR V alpha 24-J alpha Q and V alpha 14-J alpha 18 rearrangements in humans and mice, respectively, and ar ...

2003

Human immunodeficiency virus type 1 matrix protein interacts with cellular protein HO3

Didier Trono

The matrix (MA) protein of human immunodeficiency virus type 1 (HIV-1) plays a critical role in virion morphogenesis and fulfills important functions during the early steps of infection. In an effort to identify cellular partners of MA, a Saccharomyces cer ...

1998

Effects of HPA hormones on adapted lymphocyte responsiveness to repeated stress

Maria del Carmen Sandi Perez

Acute stress-induced immune alterations can result in adapted function with prolonged exposure to the same stressor. The present study was designed to evaluate the possible role of the hypothalamic-pituitary-adrenocortical (HPA) axis on the adaptation of s ...

1992

Different responsiveness of spleen lymphocytes from two lines of psychogenetically selected rats (Roman high and low avoidance)

Maria del Carmen Sandi Perez

Roman high- (RHA) and low-avoidance (RLA) rats have been genetically selected on the basis of their active avoidance behavior, and have been shown to differ on numerous behavioral, neurochemical and neuroendocrine parameters, especially in response to stre ...

1991

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