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Concept
Karen Davis (neuroscientist)
Summary
Karen D. Davis is a neuroscience professor at the University of Toronto, and is the head of Division of Brain, Imaging & Behaviour, Krembil Research Institute at the University Health Network. Davis was inducted into the Johns Hopkins Society of Scholars in 2009, the Canadian Academy of Health Sciences in 2018 and the Royal Society of Canada in 2020 and is currently the president of the Canadian Pain Society.
She has previously held a Canada Research Chair in Brain and Behaviour. and was a Mayday Pain and Society Fellow.
Davis' main interest is the central mechanisms underlying acute and chronic pain and temperature perception, the influence of attention, and mechanisms of plasticity under normal conditions and in patients with neurologic or psychiatric disorders. A variety of experimental techniques are used, including functional brain imaging (fMRI, PET, MEG), psychophysical and cognitive assessment, and electrophysiological recordings in the thalamus and cortex. Davis' laboratory has developed innovative brain-imaging approaches, culminating in the first functional MRI images of brain networks underlying the human pain experience and the first images of the impact of deep brain stimulation for Parkinsonian tremor.
Davis has also worked on variety of chronic pain conditions, concussion, and phantom pain. She has demonstrated that findings support the hypothesis that the thalamic representation of the amputated limb remains functional in amputees with phantom sensations. Through several studies, she has shown important interactions between pain and cognition, by studying how brain networks shift their function towards pain while multitasking on cognitive tasks (Seminowicz et al., 2007; Erpelding et al., 2013) or when processing multimodal sensory information (Downar et al., 2000) or during mind wandering (Kucyi et al., 2013). She has introduced two influential theories that builds on the neuromatrix concept of Melzack. In the "pain switch" concept (Davis et al.
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