Concept
Bone healing
Related publications (145)
High-speed photography of the development of microdamage in trabecular bone during compression
Georg Fantner, Blake William Erickson
The mechanical properties of healthy and diseased bone tissue were extensively studied in mechanical tests. Most of this research was motivated by the immense costs of health care and social impacts due to osteoporosis in post-menopausal women and the aged ...
2006The Influence of Matrix Modification on Fracture Mechanisms in Rubber Toughened Polymethylmethacrylate
John Christopher Plummer, Laure Dupuits Lalande
The fracture behavior of composite rubber particle-toughened polymethylmethacrylate has been investigated over a wide range of test speeds, encompassing impact conditions. When the entanglement density of the matrix was increased and its glass transition t ...
2006Delay of intracortical bone remodelling following a stress change: a theoretical and experimental study
Alexandre Terrier, Lalaonirina Rakotomanana Ravelonarivo
BACKGROUND: A theoretical model and an experimental setup were specifically designed to identify and determine the delay of the cortical bone response (restricted to mineralization and demineralization) to a stress change. METHODS: The in vivo experiment c ...
2005Sacrificial bonds and hidden length dissipate energy as mineralized fibrils separate during bone fracture
Properties of the organic matrix of bone(1) as well as its function in the microstructure(2) could be the key to the remarkable mechanical properties of bone(3). Previously, it was found that on the molecular level, calcium-mediated sacrificial bonds incre ...
2005Novel techniques for high-resolution functional imaging of teabecular bone
Georg Fantner, Randoald Müller
In current biological and biomedical research, quantitative endpoints have become an important factor of success. Classically, such endpoints were investigated with 2D imaging, which is usually destructive and the 3D character of tissue gets lost. 3D imagi ...
2005High-speed photography of human trabecular bone during compression
Georg Fantner, Blake William Erickson
The mechanical properties of healthy and diseased bone tissue are extensively studied in mechanical tests. Most of this research is motivated by the immense costs of health care and social impacts due to osteoporosis in post-menopausal women and the aged. ...
2005Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering
Matthias Lütolf, Jeffrey Alan Hubbell
A review. New generations of synthetic biomaterials are being developed at a rapid pace for use as three-dimensional extracellular microenvironments to mimic the regulatory characteristics of natural extracellular matrixes (ECMs) and ECM-bound growth facto ...
2005Enhanced bone formation in lipodystrophic PPARgamma(hyp/hyp) mice relocates haematopoiesis to the spleen
The peroxisome proliferator-activated receptor gamma (PPARgamma) controls adipogenesis and metabolism. We demonstrate here that the absence of PPARgamma in fat has potent osteogenic activities, which affect haematopoiesis. The congenital absence of PPARgam ...
2004Orthopedic implants used as drug delivery systems
Total Hip Replacement (THR) is today a routine procedure executed more than 800'000 times per year worldwide. THR gives generally satisfactory results, although the quality of outcome is inversely proportional to the age of the patient. In parallel, there ...
EPFL2004