Concept
Pilus
Related publications (39)
Dangerous acquaintances: the interplay between type IV pili and the type VI secretion system during Vibrio cholerae's environmental lifestyle
Cholera, caused by the bacterium Vibrio cholerae, has affected humanity throughout history and still impacts millions of people every year. Apart from being a human pathogen, V. cholerae is a common member of the aquatic environment. Due to this natural re ...
EPFL2024Interactions between pili affect the outcome of bacterial competition driven by the type VI secretion system
Melanie Blokesch, Anne-Florence Raphaëlle Bitbol, Alexandre Lemopoulos, Richard Marie Servajean, Simon Bernhard Otto
The bacterial type VI secretion system (T6SS) is a widespread, kin-discriminatory weapon capable of shaping microbial communities. Due to the system’s dependency on contact, cellular interactions can lead to either competition or kin protection. Cell-to-ce ...
2024Machine learning method for the classification of the state of living organisms' oscillations
Sandor Kasas, María Inés Villalba
The World Health Organization highlights the urgent need to address the global threat posed by antibiotic-resistant bacteria. Efficient and rapid detection of bacterial response to antibiotics and their virulence state is crucial for the effective treatmen ...
Frontiers Media Sa2024Interactions between pili affect the outcome of bacterial competition driven by the type VI secretion system
Melanie Blokesch, Anne-Florence Raphaëlle Bitbol, Alexandre Lemopoulos, Richard Marie Servajean, Simon Bernhard Otto
The bacterial type VI secretion system (T6SS) is a widespread, kin-discriminatory weapon capable of shaping microbial communities. Due to the system's dependency on contact, cellular interactions can lead to either competition or kin protection. Cell-to-ce ...
2023Two antagonistic response regulators control Pseudomonas aeruginosa polarization during mechanotaxis
Alexandre Louis André Persat, Lorenzo Anton-Louis Talà, Xavier Jean-Yves Pierrat, Joanne Netter Engel, Marco Julian Kühn
The opportunistic pathogen Pseudomonas aeruginosa adapts to solid surfaces to enhance virulence and infect its host. Type IV pili (T4P), long and thin filaments that power surface-specific twitching motility, allow single cells to sense surfaces and contro ...
WILEY2023Natural competence of the pathogen Acinetobacter baumannii: an elusive phenomenon
Natural competence for transformation is an important driver of horizontal DNA exchange between different organisms. This can result in accumulation of dangerous genetic features, such as antibiotic resistance genes, in a single organism. One example of an ...
EPFL2022Characterization of Pseudomonas aeruginosa mechanosensing through label-free imaging of type IV pili
Bacteria are ubiquitously found in all sorts of environment. They're found in the ocean, soil, or even in our guts or on our skin. Independently of their niche, they can transition from a planktonic state were they freely swim in an aqueous environment to ...
EPFL2022Type 1 piliated uropathogenic Escherichia coli hijack the host immune response by binding to CD14
A key attribute of persistent or recurring bacterial infections is the ability of the pathogen to evade the host's immune response. Many Enterobacteriaceae express type 1 pili, a pre-adapted virulence trait, to invade host epithelial cells and establish pe ...
eLIFE SCIENCES PUBL LTD2022Engineering synthetic adhesins for biophysical investigation and rewiring of host-microbe interactions
Host attachment is often a critical step in the onset of pathogenesis. To attach to host cells, bacteria have evolved a range of adhesins that bind to specific receptors. Some of these adhesins have been thoroughly characterized using biochemical technique ...
EPFL2022Pilus production in Acinetobacter baumannii is growth phase dependent and essential for natural transformation
Acinetobacter baumannii is a severe threat to human health as a frequently multidrug-resistant hospital-acquired pathogen. Part of the danger from this bacterium comes from its genome plasticity and ability to evolve quickly by taking up and recombining ex ...
2021