Stephen J. O'Brien (born 1944) is an American geneticist. He is known for his research contributions in comparative genomics, virology, genetic epidemiology, mammalian systematics and species conservation. Member of the National Academy of Sciences and a Foreign Member of the Russian Academy of Sciences. Author or co-author of over 850 scientific articles and the editor of fourteen volumes.From 1986 to 2011, O'Brien served as Chief of the Laboratory of Genomic Diversity at the National Cancer Institute (NCI), National Institutes of Health (NIH). In December 2011, he created the Theodosius Dobzhansky Center for Genome Bioinformatics (named after Theodosius Dobzhansky) at St. Petersburg State University, Russia as Chief Scientific Officer.In January 2013, he joined the Faculty as Professor at the Oceanographic Center, Nova Southeastern University, Ft Lauderdale Florida.Since November 2019, O'Brien serves as Professor at the Center of Genomic Diversity at ITMO University, St. Peter
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