Biosimulation is a computer-aided mathematical simulation of biological processes and systems and thus is an integral part of systems biology. Due to the complexity of biological systems simplified models are often used, which should only be as complex as necessary.
The aim of biosimulations is model-based prediction of the behaviour and the dynamics of biological systems e.g. the response of an organ or a single cell towards a chemical. However the quality of model-based predictions strongly depends on the quality of the model, which in turn is defined by the quality of the data and the profoundness of the knowledge.
Biosimulation is becoming increasingly important for drug development. Since on average only 11% of all drug candidates
are approved, it is anticipated that biosimulation may be the tool to predict whether a candidate drug will fail in the development process e.g. in clinical trials due to adverse side effects, bad pharmacokinetics or even toxicity. T