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The hindbrain or rhombencephalon or lower brain is a developmental categorization of portions of the central nervous system in vertebrates. It includes the medulla, pons, and cerebellum. Together they support vital bodily processes. Rhombomeres Rh3-Rh1 form the metencephalon. The metencephalon is composed of the pons and the cerebellum; it contains: a portion of the fourth (IV) ventricle, the trigeminal nerve (CN V), abducens nerve (CN VI), facial nerve (CN VII), and a portion of the vestibulocochlear nerve (CN VIII). Rhombomeres Rh8-Rh4 form the myelencephalon. The myelencephalon forms the medulla oblongata in the adult brain; it contains: a portion of the fourth ventricle, the glossopharyngeal nerve (CN IX), vagus nerve (CN X), accessory nerve (CN XI), hypoglossal nerve (CN XII), and a portion of the vestibulocochlear nerve (CN VIII). The hindbrain is homologous to a part of the arthropod brain known as the sub-oesophageal ganglion, in terms of the genes that it expresses and its position in between the brain and the nerve cord. It has been suggested that the hindbrain first evolved in the Urbilaterian—the last common ancestor of chordates and arthropods—between 570 and 555 million years ago. A rare brain disease of the cerebellum is rhombencephalosynapsis characterized by an absent or partially formed vermis. Symptoms can include truncal ataxia. The disorder is a main feature of Gomez-Lopez-Hernandez syndrome.

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The myelencephalon or afterbrain is the most posterior region of the embryonic hindbrain, from which the medulla oblongata develops. During fetal development, divisions of the neural tube that give rise to the hindbrain (rhombencephalon) and the other primary vesicles (forebrain and midbrain) occur at just 28 days after conception. With the exception of the midbrain, these primary vesicles undergo further differentiation at 5 weeks after conception to form the myelencephalon and the other secondary vesicles.

The metencephalon is the embryonic part of the hindbrain that differentiates into the pons and the cerebellum. It contains a portion of the fourth ventricle and the trigeminal nerve (CN V), abducens nerve (CN VI), facial nerve (CN VII), and a portion of the vestibulocochlear nerve (CN VIII). The metencephalon develops from the higher/rostral half of the embryonic rhombencephalon, and is differentiated from the myelencephalon in the embryo by approximately 5 weeks of age.

The pons (from Latin pons, "bridge") is part of the brainstem that in humans and other bipeds lies inferior to the midbrain, superior to the medulla oblongata and anterior to the cerebellum. The pons is also called the pons Varolii ("bridge of Varolius"), after the Italian anatomist and surgeon Costanzo Varolio (1543–75). This region of the brainstem includes neural pathways and tracts that conduct signals from the brain down to the cerebellum and medulla, and tracts that carry the sensory signals up into the thalamus.

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