Concept
Clinical trial
Related publications (652)
Using Negative Control Populations to Assess Unmeasured Confounding and Direct Effects
Sometimes treatment effects are absent in a subgroup of the population. For example, penicillin has no effect on severe symptoms in individuals infected by resistant Staphylococcus aureus, and codeine has no effect on pain in individuals with certain polym ...
Lippincott Williams & Wilkins2024Iron-carbohydrate complexes treating iron anaemia: Understanding the nano-structure and interactions with proteins through orthogonal characterisation
Antonia Neels, Marianne Liebi, Tiberiu Totu
Intravenous (IV) iron-carbohydrate complexes are widely used nanoparticles (NPs) to treat iron deficiency anaemia, often associated with medical conditions such as chronic kidney disease, heart failure and various inflammatory conditions. Even though a ple ...
Elsevier2024Augmenting locomotor perception by remapping tactile foot sensation to the back
Olaf Blanke, Mohamed Bouri, Oliver Alan Kannape, Atena Fadaeijouybari, Selim Jean Habiby Alaoui
Background :Sensory reafferents are crucial to correct our posture and movements, both reflexively and in a cognitively driven manner. They are also integral to developing and maintaining a sense of agency for our actions. In cases of compromised reafferen ...
2024Clinically compliant cryopreservation of differentiated retinal pigment epithelial cells
Gioele La Manno, Alex Russell Lederer, Cheng Zhao
Background aims: Age-related macular degeneration (AMD) is the most common cause of blindness in elderly patients within developed countries, affecting more than 190 million worldwide. In AMD, the retinal pigment epithelial (RPE) cell layer progressively d ...
Elsevier Sci Ltd2024Efficacy and safety of transcranial direct current stimulation to the ipsilesional motor cortex in subacute stroke (NETS): a multicenter, randomized, double-blind, placebo-controlled trial
Background Each year, five million people are left disabled after stroke. Upper -extremity (UE) dysfunction is a leading problem. Neuroplasticity can be enhanced by non-invasive brain stimulation (NIBS) but evidence from large, randomized multicenter trial ...
Elsevier2024The role of computational methods in cardiovascular medicine: a narrative review
Alfio Quarteroni, Luca Dede', Christian Vergara, Stefano Pagani
Background and Objective: Computational models of the cardiovascular system allow for a detailed and quantitative investigation of both physiological and pathological conditions, thanks to their ability to combine clinical-possibly patient-specific-data wi ...
Ame Publishing Company2024How to Count Coughs: An Event-Based Framework for Evaluating Automatic Cough Detection Algorithm Performance
David Atienza Alonso, Tomas Teijeiro Campo, Lara Orlandic, Jonathan Dan, Jérôme Paul Rémy Thevenot
Chronic cough disorders are widespread and challenging to assess because they rely on subjective patient questionnaires about cough frequency. Wearable devices running Machine Learning (ML) algorithms are promising for quantifying daily coughs, providing c ...
arXiv2024Beam Loss Simulations for the Proposed TATTOS Beamline at HIPA
IMPACT (Isotope and Muon Production with Advanced Cyclotron and Target Technologies) is a proposed initia- tive envisaged for the high-intensity proton accelerator fa- cility (HIPA) at the Paul Scherrer Institute (PSI). As part of IMPACT, a radioisotope ta ...
JACoW (Joint Accelerator Conferences Website)2024Quantitative T2 Mapping of Acute Pancreatitis
Background: Quantification of the T2 signal by means of T2 mapping in acute pancreatitis (AP) has the potential to quantify the parenchymal edema. Quantitative T2 mapping may overcome the limitations of previously reported scoring systems for reliable asse ...
Hoboken2024A First-in-Human Randomized Study to Assess the Safety, Tolerability, Pharmacokinetics, and Neutralization Profile of Two Investigational Long-Acting Anti-SARS-CoV-2 Monoclonal Antibodies
Didier Trono, Norman Lionel Moullan
Introduction: COVID-19 remains a significant risk for the immunocompromised given their lower responsiveness to vaccination or infection. Therefore, passive immunity through long-acting monoclonal antibodies (mAbs) offers a needed approach for pre-exposure ...
2024