Concept

Systole

Related publications (45)

An Animal-Specific FSI Model of the Abdominal Aorta in Anesthetized Mice

Nikolaos Stergiopoulos, Bram Trachet, Patrick Segers

Recent research has revealed that angiotensin II-induced abdominal aortic aneurysm in mice can be related to medial ruptures occurring in the vicinity of abdominal side branches. Nevertheless a thorough understanding of the biomechanics near abdominal side ...

Springer2015

Computational generation of the Purkinje network driven by clinical measurements: The case of pathological propagations

Alfio Quarteroni, Fabio Nobile, Christian Vergara, Elena Faggiano

To properly describe the electrical activity of the left ventricle, it is necessary to model the Purkinje fibers, responsible for the fast and coordinate ventricular activation, and their interaction with the muscular propagation. The aim of this work is t ...

2014

Isogeometric Analysis of Electrophysiological Models on Surfaces

Alessandro Samuele Patelli

In this project we numerically simulate electrophysiological models for cardiac applications by means of Isogeometric Analysis. Specifically, we aim at understanding the advantages of using high order continuous NURBS (Non-UniformRational B-Splines) basis ...

2014

Markers for risk to develop atrial fibrillation based on a new electrocardiographic tool

Atrial fibrillation (AF) is the most important trigger for heart failure and stroke. Reliable methods for predicting AF are lacking and ECG analysis could improve this process. P-wave characteristics in the ECG are an important source of information in the ...

2013

Modeling Atrial Pacing

We present a model-based study of therapeutical approaches to atrial fibrillation with a focus on pacing. After a systematic evaluation of different atrial pacing sites, we selected pacing from the septum area and designed a novel septum pacing protocol fo ...

2013

Deletion of Sirt3 does not affect atherosclerosis but accelerates weight gain and impairs rapid metabolic adaptation in LDL receptor knockout mice: implications for cardiovascular risk factor development

Johan Auwerx, Julien Weber, Yuan Liu, Chad Brokopp

Sirt3 is a mitochondrial NAD(+)-dependent deacetylase that governs mitochondrial metabolism and reactive oxygen species homeostasis. Sirt3 deficiency has been reported to accelerate the development of the metabolic syndrome. However, the role of Sirt3 in a ...

Springer Verlag2013

Measures of spatiotemporal organization differentiate persistent from long-standing atrial fibrillation

Jean-Marc Vesin, Laurent Renaud Uldry, Yann Prudat, Jérôme Sébastien Van Zaen, Lukas Kappenberger

This study presents an automatic diagnostic method for the discrimination between persistent and long-standing atrial fibrillation (AF) based on the surface electrocardiogram (ECG). Standard 12-lead ECG recordings were acquired in 53 patients with either p ...

Oxford Univ Press2012

Therapeutic Strategies for the Treatment of Atrial Fibrillation

Laurent Renaud Uldry

Atrial fibrillation is the most common cardiac rhythm disorder encountered in clinical practice, often leading to severe complications such as heart failure and stroke. This arrhythmia, increasing in prevalence with age, already affects several millions of ...

EPFL2011

Characterization of Atrial Repolarization Alternans and Activation Time Kinetics based on Intracardiac Electrograms

Florian Jousset

Interdisciplinary collaboration between physicians and engineers is now widespread in fundamental and clinical studies, due to the increasing complexity of the physiological problems tackled, and the development of novel measurement devices and data analys ...

EPFL2011

Long-term intermittent atrial tachycardia decreases activation recovery interval, flattens its kinetics and blunts its rate dependence before sustained atrial fibrillation

Jean-Marc Vesin, Florian Jousset, Etienne Pruvot

Introduction: We recently observed in an acute ovine model of pacing-induced atrial tachycardia (PIAT) that rapid atrial capture and fibrillatory conduction were prevented by 2:1 capture mediated by decreased excitability. We hypothesize that long-term int ...

2010

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