Concept
Esophageal cancer
Related publications (94)
NMR and MS reveal characteristic metabolome atlas and optimize esophageal squamous cell carcinoma early detection
Lijing Xin, Yubo Zhao, Yan Lin, Wei Ye
Metabolic changes precede malignant histology. However, it remains unclear whether detectable characteristic metabolome exists in esophageal squamous cell carcinoma (ESCC) tissues and biofluids for early diagnosis. Here, we conduct NMR- and MS-based metabo ...
Nature Portfolio2024Next-Generation Modeling of Cancer Using Organoids
Wouter Richard Karthaus, Jillian Rose Love
In the last decade, organoid technology has become a cornerstone in cancer research. Organoids are long-term primary cell cultures, usually of epithelial origin, grown in a three-dimensional (3D) protein matrix and a fully defined medium. Organoids can be ...
Cold Spring Harbor Lab Press, Publications Dept2024Multimodal fusion of liquid biopsy and CT enhances differential diagnosis of early-stage lung adenocarcinoma
Jiancheng Yang, Li Zhang, Jun Lu, Hua Zhong, Yunhua Zhang
This research explores the potential of multimodal fusion for the differential diagnosis of early-stage lung adenocarcinoma (LUAD) (tumor sizes < 2 cm). It combines liquid biopsy biomarkers, specifically extracellular vesicle long RNA (evlRNA) and the comp ...
Berlin2024The role of LRRK2 in lung adenocarcinoma
Lung cancer is the leading cause of cancer-related deaths worldwide and the most commonlung cancer subtype is lung adenocarcinoma (LUAD). Frequently mutated genes involveactivating mutations in KRAS and loss of function mutations in TP53. LUADs primarily a ...
EPFL2024Tumor-educated Gr1+CD11b+cells drive breast cancer metastasis via OSM/IL-6/JAK-induced cancer cell plasticity
Nadine Fournier, Manon Bulliard, Annamaria Kauzlaric, Yu-Ting Huang, Rachel Marcone
Cancer cell plasticity contributes to therapy resistance and metastasis, which represent the main causes of cancer-related death, including in breast cancer. The tumor microenvironment drives cancer cell plasticity and metastasis, and unraveling the underl ...
Amer Soc Clinical Investigation Inc2024CellCharter reveals spatial cell niches associated with tissue remodeling and cell plasticity
Daniele Tavernari, Albert Santamaria Martinez, Giovanni Ciriello
Tissues are organized in cellular niches, the composition and interactions of which can be investigated using spatial omics technologies. However, systematic analyses of tissue composition are challenged by the scale and diversity of the data. Here we pres ...
Berlin2023Cancer hallmarks intersect with neuroscience in the tumor microenvironment
The mechanisms underlying the multistep process of tumorigenesis can be distilled into a logical framework involving the acquisition of functional capabilities, the so-called hallmarks of cancer, which are collectively envisaged to be necessary for maligna ...
CELL PRESS2023Preomic profile of BxPC-3 cells after treatment with BRC4
BRCA2 and RAD51 are two proteins that play a central role in homologous recombination (HR) and DNA double strand break (DSB) repair. BRCA2 assists RAD51 fibrillation and defibrillation through binding with its eight BRC repeats, with BRC4 being one of the ...
ELSEVIER2023A PD-L1/EGFR bispecific antibody combines immune checkpoint blockade and direct anti-cancer action for an enhanced anti-tumor response
Immune checkpoint blockade (ICB) with antibodies has shown durable clinical responses in a wide range of cancer types, but the overall response rate is still limited. Other effective therapeutic modalities to increase the ICB response rates are urgently ne ...
TAYLOR & FRANCIS INC2023Deep learning-based solid component measuring enabled interpretable prediction of tumor invasiveness for lung adenocarcinoma
Jiancheng Yang, Li Zhang, Xinchao Wang, Hua Sun
Background: The nature of the solid component of subsolid nodules (SSNs) can indicate tumor pathological invasiveness. However, preoperative solid component assessment still lacks a reference standard.Methods: In this retrospective study, an AI algorithm w ...
Clare2023