Concept
Phospholipid
Related publications (82)
Quantified interface chemistry and biophysics via water imaging
High throughput wide-field second harmonic imaging enables the label-free imaging of interfacial (< 3 nm thick) water, with a spatial resolution of similar to 370 nm using similar to 100 ms acquisition times per image. The obtained interfacial orientationa ...
Spie-Int Soc Optical Engineering2024Structure and regulation of the myotonic dystrophy kinase-related Cdc42-binding kinase
Charlotte Julie Caroline Gehin
Protein kinases of the dystonia myotonica protein kinase (DMPK) family are critical regulators of actomyosin contractility in cells. The DMPK kinase MRCK1 is required for the activation of myosin, leading to the develop-ment of cortical tension, apical con ...
CELL PRESS2023Inhibition of CERS1 in skeletal muscle exacerbates age-related muscle dysfunction
Johan Auwerx, Olivier Burri, Xiaoxu Li, Tanes Imamura de Lima, Giacomo Vincenzo Giorgio Von Alvensleben, Martin Rainer Wohlwend, Pirkka-Pekka Untamo Laurila, Ludger Jan Elzuë Goeminne, Barbara Moreira Crisol, Amélia Lalou, Renata Mangione
Age-related muscle wasting and dysfunction render the elderly population vulnerable and incapacitated, while underlying mechanisms are poorly understood. Here, we implicate the CERS1 enzyme of the de novo sphingolipid synthesis pathway in the pathogenesis ...
2023Inhibiting de novo ceramide synthesis restores mitochondrial and protein homeostasis in muscle aging
Johan Auwerx, Xiaoxu Li, Mario Romani, Tanes Imamura de Lima, Sandra Rodriguez Lopez, Jean-David Horacio Morel, Hao Li, Martin Rainer Wohlwend, Pirkka-Pekka Untamo Laurila, Ludger Jan Elzuë Goeminne, Barbara Moreira Crisol, Changmyung Oh, Dohyun Park
Disruption of mitochondrial function and protein homeostasis plays a central role in aging. However, how these processes interact and what governs their failure in aging remain poorly understood. Here, we showed that cer- amide biosynthesis controls the de ...
AMER ASSOC ADVANCEMENT SCIENCE2023Unit-cell-thick zeolitic imidazolate framework films for membrane application
Kumar Varoon Agrawal, Jian Hao, Shuqing Song, Luis Francisco Villalobos Vazquez de la Parra, Shaoxian Li, Deepu Joseph Babu, Heng-Yu Chi, Qi Liu, Yu Han
Zeolitic imidazolate frameworks (ZIFs) are a subset of metal-organic frameworks with more than 200 characterized crystalline and amorphous networks made of divalent transition metal centres (for example, Zn2+ and Co2+) linked by imidazolate linkers. ZIF th ...
NATURE PORTFOLIO2023Imaging Cu2+ binding to charged phospholipid membranes by high-throughput second harmonic wide-field microscopy
Sylvie Roke, David Roesel, Seonwoo Lee
The interaction of divalent copper ions (Cu2+) with cell membranes is crucial for a variety of physiological processes of cells, such as hormone synthesis and cellular energy production. These interactions would not be possible without membrane hydration. ...
AIP Publishing2021Cholesterol Hinders the Passive Uptake of Amphiphilic Nanoparticles into Fluid Lipid Membranes
Francesco Stellacci, Matteo Gasbarri, Ester Canepa, Giulia Rossi
Plasma membranes represent pharmacokinetic barriers for the passive transport of site-specific drugs within cells. When engineered nanoparticles (NPs) are considered as transmembrane drug carriers, the plasma membrane composition can affect passive NP inte ...
AMER CHEMICAL SOC2021Structures of three MORN repeat proteins and a re-evaluation of the proposed lipid-binding properties of MORN repeats
Charlotte Julie Caroline Gehin
MORN (Membrane Occupation and Recognition Nexus) repeat proteins have a wide taxonomic distribution, being found in both prokaryotes and eukaryotes. Despite this ubiquity, they remain poorly characterised at both a structural and a functional level compare ...
PUBLIC LIBRARY SCIENCE2020Polymer Coatings to Minimize Protein Adsorption in Solid-State Nanopores
Aleksandra Radenovic, Sanjin Marion, Sebastian James Davis, Michael Mayer
Nanopore-based resistive-pulse recordings represent a promising approach for single-molecule biophysics with applications ranging from rapid DNA and RNA sequencing to "fingerprinting" proteins. Based on advances in fabrication methods, solid-state nanopore ...
WILEY-V C H VERLAG GMBH2020Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism
Sterol regulatory element binding proteins (SREBPs) are a family of transcription factors that regulate lipid biosynthesis and adipogenesis by controlling the expression of several enzymes required for cholesterol, fatty acid, triacylglycerol and phospholi ...
Springer2019