Concept

Protein primary structure

Related publications (302)

Structure and properties of the C-terminal beta-helical domain of VgrG protein from Escherichia coli O157

The bacterial Type 6 secretion system (T6SS) translocates protein toxins (also called effectors) from the cytosol of a T6SS-carrying cell to a target cell by a syringe-like supramolecular complex resembling a contractile tail of bacteriophages. Valine-glyc ...

Oxford University Press2014

Modelling of Protein Palmitoylation Networks

Tiziano Dallavilla

S-Palmitoylation is a post-translational modification consisting in the reversible attachment of palmitate. Little is known about the mechanisms that underlie the dynamics of the process. Using computational modelling we investigated the palmitoylation- de ...

2014

Peptide ligands stabilized by small molecules

Christian Heinis, Florence Pojer, Alessandro Angelini, Shiyu Chen, Davide Bertoldo

Bicyclic peptides generated through directed evolution by using phage display offer an attractive ligand format for the development of therapeutics. Being nearly 100-fold smaller than antibodies, they promise advantages such as access to chemical synthesis ...

Wiley-V C H Verlag Gmbh2014

A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease

Ozgün Gökce, Davide Franceschini

Protein acetylation, which is central to transcriptional control as well as other cellular processes, is disrupted in Huntington's disease (HD). Treatments that restore global acetylation levels, such as inhibiting histone deacetylases (HDACs), are effecti ...

Oxford University Press2014

A New Role for Escherichia coli DsbC Protein in Protection against Oxidative Stress

Camille Véronique Bernadette Goemans

We report a new function for Escherichia coli DsbC, a protein best known for disulfide bond isomerization in the periplasm. We found that DsbC regulates the redox state of the single cysteine of the l-arabinose-binding protein AraF. This cysteine, which ca ...

2014

Performance-based approach for the retrofit of URM wall structures by RC walls

Katrin Beyer, Alessandro Paparo

In several countries of moderated seismicity, with the re-evaluation of the seismic hazard most unreinforced masonry (URM) buildings with reinforced concrete slabs failed to satisfy the seismic design check. A possible seismically retrofit solution consist ...

2014

Ping-Pong Protons: How Hydrogen Bonding Networks Facilitate Heterolytic Bond Cleavages in Peptide Radical Cations

Yury Tsybin, Matthew Wodrich, Konstantin Zhurov

Electron capture and electron transfer dissociation (ECD/ETD) tandem mass spectrometry (MS/MS) are commonly employed techniques for biomolecular analysis. The ECD/ETD process predominately cleaves N-C-alpha peptide backbone bonds, leading to primary sequen ...

Amer Chemical Soc2014

From Reinforcement to High-Performance Damping

Emmanuel Croisier

Biomaterials such as structure proteins are constructed from limited sets of chemical building blocks and supramolecular motifs. Nevertheless, they exhibit extraordinary properties specifically tailored for a broad range of applications because hierarchica ...

EPFL2013

Investigation of non-corrin cobalt(II)-containing sites in protein structures of the Protein Data Bank

Luciano Andres Abriata

Protein X-ray structures with non-corrin cobalt(II)-containing sites, either natural or substituting another native ion, were downloaded from the Protein Data Bank and explored to (i) describe which amino acids are involved in their first ligand shells and ...

Wiley-Blackwell2013

Proteome Digestion Specificity Analysis for Rational Design of Extended Bottom-up and Middle-down Proteomics Experiments

Yury Tsybin, Kristina Srzentic, Unige Anna Laskay

Mass spectrometry (MS)-based bottom-up proteomics (BUP) is currently the method of choice for large-scale identification and characterization of proteins present in complex samples, such as cell lysates, body fluids, or tissues. Technically, BUP relies on ...

Amer Chemical Soc2013

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