Concept
Phenotype
Related publications (149)
Wide-scale identification of novel/eliminated genes responsible for evolutionary transformations
BackgroundIt is generally accepted that most evolutionary transformations at the phenotype level are associated either with rearrangements of genomic regulatory elements, which control the activity of gene networks, or with changes in the amino acid conten ...
2023Environment-dependent epistasis increases phenotypic diversity in gene regulatory networks
Mutations to gene regulatory networks can be maladaptive or a source of evolutionary novelty. Epistasis con-founds our understanding of how mutations affect the expression patterns of gene regulatory networks, a chal-lenge exacerbated by the dependence of ...
AMER ASSOC ADVANCEMENT SCIENCE2023CHARACTERIZING THE RESILIENCE AND ADAPTATION OF BIOFILM COMMUNITIES TO CLIMATE CHANGE IN GLACIER-FED STREAMS
Tom Ian Battin, Hannes Markus Peter, Grégoire Marie Octave Edouard Michoud, Nicola Deluigi, David Touchette, Martina Gonzalez Mateu, Florian Baier
Biofilms conform the dominant microbial lifestyle in alpine streams where they are major contributors to carbon and nutrient cycling. However, relatively little is known about their adaptive capacity to climate change as water temperature rises and hydrolo ...
2023Sulfurospirillum diekertiae sp. nov., a tetrachloroethene-respiring bacterium isolated from contaminated soil
Christof Holliger, Julien Maillard, Junxiong Wang
Two anaerobic, tetrachloroethene- (PCE-) respiring bacterial isolates, designated strain ACSDCE T and strain ACSTCE, were characterized using a polyphasic approach. Cells were Gram-stain-negative, motile, non-spore-forming and shared a vibrioid- to spirill ...
2023Impact of population size on early adaptation in rugged fitness landscapes
Anne-Florence Raphaëlle Bitbol, Richard Marie Servajean
Owing to stochastic fluctuations arising from finite population size, known as genetic drift, the ability of a population to explore a rugged fitness landscape depends on its size. In the weak mutation regime, while the mean steady-state fitness increases ...
ROYAL SOC2023Selective elimination of enterovirus genotypes by activated sludge and chlorination
Enteroviruses, which are commonly circulating viruses shed in the stool, are released into the sewage system and only partially removed or inactivated, resulting in the discharge of infectious enteroviruses into the environment. Activated sludge and chlori ...
2023Sex-dimorphic and age-dependent organization of 24-hour gene expression rhythms in humans
Felix Naef, Cédric Gobet, Lorenzo Talamanca
The circadian clock modulates human physiology. However, the organization of tissue-specific gene expression rhythms and how these depend on age and sex is not defined in humans. We combined data from the Genotype-Tissue Expression (GTEx) project with an a ...
AMER ASSOC ADVANCEMENT SCIENCE2023A tool for mapping microglial morphology, morphOMICs, reveals brain-region and sex-dependent phenotypes
Kathryn Hess Bellwald, Lida Kanari, Martina Scolamiero
Environmental cues influence the highly dynamic morphology of microglia. Strategies to characterize these changes usually involve user-selected morphometric features, which preclude the identification of a spectrum of context-dependent morphological phenot ...
NATURE PORTFOLIO2022Current challenges in understanding the role of enhancers in disease
Enhancers play a central role in the spatiotemporal control of gene expression and tend to work in a cell-type-specific manner. In addition, they are suggested to be major contributors to phenotypic variation, evolution and disease. There is growing eviden ...
NATURE PORTFOLIO2022Towards mouse genetic-specific RNA-sequencing read mapping
Genetic variations affect behavior and cause disease but understanding how these variants drive complex traits is still an open question. A common approach is to link the genetic variants to intermediate molecular phenotypes such as the transcriptome using ...
2022