Concept

P53

Related publications (119)

Cytotoxic Property of Surfactant-Cobalt(III) Complexes on a Human Breast Cancer Cell Line

The cancer chemotherapeutic potential of surfactant-cobalt(III) complexes, cis-Co(bpy)(2)(C14H29NH2)Cl(2) center dot 3 H2O (1) and cis-Co(phen)(2)(C14H29NH2)Cl(2) center dot 3 H2O (2) (bpy 2,2 '-bipyridine, phen 1,10-phenanthroline) on MCF- ...

2011

Response and resistance to NF-κB inhibitors in mouse models of lung adenocarcinoma

Etienne Meylan

Lung adenocarcinoma is a frequently diagnosed cancer type and a leading cause of cancer death worldwide. We recently demonstrated in an autochthonous mouse model of this disease that genetic inhibition of the NF-κB pathway affects both the initiation and m ...

2011

ID4 regulates mammary gland development by suppressing p38MAPK activity

Yiming Li, Cathrin Brisken, Marian Caikovski, Xiuwei Zhang, Jun Dong

The ID family of helix-loop-helix proteins regulates cell proliferation and differentiation in many different developmental pathways, but the functions of ID4 in mammary development are unknown. We report that mouse Id4 is expressed in cap cells, basal cel ...

2011

IRF6 is a mediator of Notch pro-differentiation and tumour suppressive function in keratinocytes

Freddy Radtke, Matteo Di Piazza, Piotr Dziunycz

While the pro-differentiation and tumour suppressive functions of Notch signalling in keratinocytes are well established, the underlying mechanisms remain poorly understood. We report here that interferon regulatory factor 6 (IRF6), an IRF family member wi ...

Nature Publishing Group2011

Genomic instability in induced stem cells

Didier Trono, Marc Samuel Friedli

The ability to reprogram adult cells into stem cells has raised hopes for novel therapies for many human diseases. Typical stem cell reprogramming protocols involve expression of a small number of genes in differentiated somatic cells with the c-Myc and Kl ...

Nature Publishing Group2011

Redundancy and specificity of multiple Trigger Factor chaperones in Desulfitobacteria

Christof Holliger, Julien Maillard

The ribosome-bound Trigger Factor (TF) chaperone assists folding of newly synthesized polypeptides and participates in the assembly of macromolecular complexes. In the present study we showed that multiple distinct TF paralogues are present in genomes of D ...

2011

The cyclin E regulator cullin 3 prevents mouse hepatic progenitor cells from becoming tumor-initiating cells

Benita Wolf

Cyclin E is often overexpressed in cancer tissue, leading to genetic instability and aneuploidy. Cullin 3 (Cul3) is a component of the BTB-Cul3-Rbx1 (BCR) ubiquitin ligase that is involved in the turnover of cyclin E. Here we show that liver-specific ablat ...

2010

Marker-independent identification of glioma-initiating cells

Rolf Gruetter, Cristina Ramona Cudalbu

Tumor-initiating cells with stem cell properties are believed to sustain the growth of gliomas, but proposed markers such as CD133 cannot be used to identify these cells with sufficient specificity. We report an alternative isolation method purely based on ...

Nature Publishing Group2010

Notch1 Functions as a Tumor Suppressor in a Model of K-ras-Induced Pancreatic Ductal Adenocarcinoma

Freddy Radtke

K-ras is the most commonly mutated oncogene in pancreatic cancer and its activation in murine models is sufficient to recapitulate the spectrum of lesions seen in human pancreatic ductal adenocarcinoma (PDAC). Recent studies suggest that Notch receptor sig ...

American Association for Cancer Research2010

Antagonistic roles of Notch and p63 in controlling mammary epithelial cell fates

Cathrin Brisken, Maryse Fiche

The breast epithelium has two major compartments, luminal and basal cells, that are established and maintained by poorly understood mechanisms. The p53 homolog, p63, is required for the formation of mammary buds, but its function in the breast after birth ...

Nature Publishing Group2010

Graph Chatbot

Chat with Graph Search

Ask any question about EPFL courses, lectures, exercises, research, news, etc. or try the example questions below.

DISCLAIMER: The Graph Chatbot is not programmed to provide explicit or categorical answers to your questions. Rather, it transforms your questions into API requests that are distributed across the various IT services officially administered by EPFL. Its purpose is solely to collect and recommend relevant references to content that you can explore to help you answer your questions.