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Reliable activation of inhibitory pathways is essential for maintaining the balance between excitation and inhibition during cortical activity. Little is known, however, about the activation of these pathways at the level of the local neocortical microcirc ...
In this study, we examined whether chronic stress in adulthood can exert long-term effects on spatial-cognitive abilities and on the survival of newborn hippocampal cells in aging animals. Male Wistar rats were subjected to chronic unpredictable stress at ...
One of the fundamental and puzzling questions in vision research is how objects are segmented from their backgrounds and how object formation evolves in time. The recently discovered shine-through effect allows one to study object segmentation and object f ...
Anatomical, electrophysiological and molecular diversity of basket cell-like interneurons in layers II-IV of rat somatosensory cortex were studied using patch-clamp electrodes filled with biocytin. This multiparametric study shows that neocortical basket c ...
Large network monitoring of electrogenic cells by means of micro electrode arrays (MEA) has become a valuable methodology in electrophysiology. In order to understand the mechanisms of learning (plasticity) and memory in fundamental neuroscience it is impe ...
Although previous Northern blot and in situ hybridization studies suggested that neurons express the monocarboxylate transporter MCT2, subsequent immunohistochemical analyzes either failed to confirm the presence of this transporter or revealed only a low ...
MCT2 is the main neuronal monocarboxylate transporter needed by neurons if they are to use lactate as an additional energy substrate. Previous evidence suggested that some MCT2 could be located in postsynaptic elements of glutamatergic synapses. Using post ...
The Bergmann glia is a unipolar astrocyte in the cerebellar cortex, displaying a tight association with Purkinje cells. The cell bodies of Bergmann glia are located in a row around Purkinje cell somata; they extend radially arranged Bergmann fibers which e ...
This article throws new light on the possible role of synapses in information transmission through theoretical analysis and computer simulations. We show that the internal dynamic state of a synapse may serve as a transient memory buffer that stores inform ...
Structural and functional diversity of GABAergic interneurons has become increasingly central in our understanding of the elemental steps of information processing in the brain. The use of different molecular, electrophysiological and anatomical techniques ...