Concept

Lactic acidosis

Related publications (62)

Inhibition of HIV-1 in cell culture by oligonucleotide-loaded nanoparticles

PURPOSE: To investigate the potential use of polymeric nanoparticles for the delivery of antisense oligonucleotides in HIV-1-infected cell cultures. METHODS: Phosphorothioate oligonucleotides were encapsulated into poly (D,L-lactic acid) nanoparticles. Two ...

2001

Differential messenger RNA distribution of lactate dehydrogenase LDH-1 and LDH-5 isoforms in the rat brain

Pierre Magistretti, Luc Pellerin

The role of lactate in brain energy metabolism has recently received renewed attention. Although blood-borne monocarboxylates such as lactate poorly cross the blood-brain barrier in the adult brain, lactate produced within the brain parenchyma may be a sui ...

2000

Cellular mechanisms of brain energy metabolism and their relevance to functional brain imaging

Pierre Magistretti, Luc Pellerin

Despite striking advances in functional brain imaging, the cellular and molecular mechanisms that underlie the signals detected by these techniques are still largely unknown. The basic physiological principle of functional imaging is represented by the tig ...

1999

Self-assembling biomaterials

Harm-Anton Klok

A new class of molecules for the preparation of self-assembling biomaterials were synthesized. These molecules consist of a cholesteryl-moiety attached via an oligo(ethylene oxide) or oligo(L-lactic acid) segment to a biologically relevant headgroup. The o ...

1998

Expression of monocarboxylate transporter mRNAs in mouse brain: support for a distinct role of lactate as an energy substrate for the neonatal vs. adult brain

Pierre Magistretti, Jean-Luc Martin, Luc Pellerin

Under particular circumstances like lactation and fasting, the blood-borne monocarboxylates acetoacetate, beta-hydroxybutyrate, and lactate represent significant energy substrates for the brain. Their utilization is dependent on a transport system present ...

1998

A mouse model for the renal salt-wasting syndrome pseudohypoaldosteronism

Qian Wang, Friedrich Beermann

Aldosterone-dependent epithelial sodium transport in the distal nephron is mediated by the absorption of sodium through the highly selective, amiloride-sensitive epithelial sodium channel (ENaC) made of three homologous subunits (alpha, beta, and gamma). I ...

1997

Excitatory amino acids stimulate aerobic glycolysis in astrocytes via an activation of the Na+/K+ ATPase

Pierre Magistretti, Luc Pellerin

Astrocytes appear to be ideally localized to couple neuronal activity to energy metabolism. First, specialized processes, the astrocytic end-feet surround blood vessels, the source of glucose for the brain. Second, other processes ensheath synapses and exp ...

1996

Selective distribution of lactate dehydrogenase isoenzymes in neurons and astrocytes of human brain

Pierre Magistretti, Luc Pellerin

In vertebrates, the interconversion of lactate and pyruvate is catalyzed by the enzyme lactate dehydrogenase. Two distinct subunits combine to form the five tetrameric isoenzymes of lactate dehydrogenase. The LDH-5 subunit (muscle type) has higher maximal ...

1996

Continuous production of lactic acid from whey permeate by Lactobacillus helveticus in a cell-recycle reactor

Urs von Stockar

The prodn. of lactic acid in a cell-recycle reactor was investigated. Studies were conducted with L. helveticus on a supplemented whey permeate medium. At 42 Deg and pH 5.5, the biomass was kept const. at 21.3 g/L. The volumetric lactic acid productivity w ...

1991

Continuous production of lactic acid from whey permeate by Lactobacillus helveticus in two chemostats in series

Urs von Stockar

The effect of diln. rate on the prodn. of lactic acid from whey permeate by L. helveticus was investigated. In the 1st chemostat of a 2-stage system, total conversion (98.1%) and max. lactic acid concn. (43.7 g/L) were obtained at a diln. rate (D1tot) of 0 ...

1990

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