Concept

Molecular clock

Related publications (105)

The ancient evolutionary origins of Scleractinia revealed by azooxanthellate corals

Anders Meibom, Jaroslaw Hubert Stolarski

Background: Scleractinian corals are currently a focus of major interest because of their ecological importance and the uncertain fate of coral reefs in the face of increasing anthropogenic pressure. Despite this, remarkably little is known about the evolu ...

2011

Population-specific expression analysis (PSEA) reveals molecular changes in diseased brain

Doris Chau Voo Thu

Human diseases are often accompanied by histological changes that confound interpretation of molecular analyses and identification of disease-related effects. We developed population-specific expression analysis (PSEA), a computational method of analyzing ...

Nature Publishing Group2011

Protein-Binding Microarray Analysis of Tumor Suppressor AP2 alpha Target Gene Specificity

Horst Vogel, Luigino Grasso, Jan Kerschgens, Tanja Egener-Kuhn, Nicolas Mermod, Hans-Anton Lehr

Cheap and massively parallel methods to assess the DNA-binding specificity of transcription factors are actively sought, given their prominent regulatory role in cellular processes and diseases. Here we evaluated the use of protein-binding microarrays (PBM ...

Public Library of Science2011

The Single-Molecule Mechanics of the Latent TGF-beta 1 Complex

Jean-Jacques Meister, Boris Hinz, Lara Buscemi Estefanell, Aurélie Formey de Saint Louvent, Josiane Angèle Charlotte Smith-Clerc, David Ramonet Jimenez

Background: TGF-beta 1 controls many pathophysiological processes including tissue homeostasis, fibrosis, and cancer progression. Together with its latency-associated peptide (LAP), TGF-beta 1 binds to the latent TGF-beta 1-binding protein-1 (LTBP-1), whic ...

Elsevier2011

Calibration in Circular Ultrasound Tomography Devices

Martin Vetterli, Amin Karbasi, Reza Parhizkar

We consider the position calibration problem in circular tomography devices, where sensors deviate from a perfect circle. We introduce a new method of calibration based on the time-of-flight measurements between sensors when the enclosed medium is homogene ...

Ieee Service Center, 445 Hoes Lane, Po Box 1331, Piscataway, Nj 08855-1331 Usa2011

PANDITplus: toward better integration of evolutionary view on molecular sequences with supplementary bioinformatics resources

Slavica Dimitrieva Janeva

Recent comparative genomic and other large-scale bioinformatics studies increasingly have been using gene annotations, functional classifications, and complimentary data from the emerging “-omics” disciplines. Indeed, such analyses have better chances to u ...

2010

Objectives, criteria and methods for using molecular genetic data in priority setting for conservation of animal genetic resources

The genetic diversity of the world's livestock populations is decreasing, both within and across breeds. A wide variety of factors has contributed to the loss, replacement or genetic dilution of many local breeds. Genetic variability within the more common ...

Wiley-Blackwell2010

Genetic diversity in farm animals - a review

Domestication of livestock species and a long history of migrations, selection and adaptation have created an enormous variety of breeds. Conservation of these genetic resources relies on demographic characterization, recording of production environments a ...

Wiley-Blackwell2010

Biogeography, Evolution and Diversity of Free-Living Protists

Thierry Jean Heger

Although widely recognized as essential actors of ecosystem processes and representing a significant part of the Earth's biodiversity, free-living protists are poorly known. Major questions concerning their diversity, ecology, and evolution remain complete ...

EPFL2010

Lumpability Abstractions of Rule-based Systems

Tatjana Petrov

The induction of a signaling pathway is characterized by transient complex formation and mutual posttranslational modification of proteins. To faithfully capture this combinatorial process in a mathematical model is an important challenge in systems biolog ...

2010

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