Concept
Renin
Related publications (16)
Altered heart cytokine profile and action potential modulation in cardiomyocytes from Mas-deficient mice
The renin-angiotensin system (RAS) is a key hormonal system. In recent years, the functional analysis of the novel axis of the RAS (ACE2/Ang-(1-7)/Mas receptor) revealed that its activation can become pro-tective against several pathologies, including card ...
ACADEMIC PRESS INC ELSEVIER SCIENCE2022Diminazene Protects Corpus Cavernosum Against Hypercholesterolemia-Induced Injury
Nikolaos Stergiopoulos, Mikaël Nils Sturny, Rafaela Fernandes Da Silva, Fabiana Pereira Da Costa Fraga, Younouss Faye
IntroductionAngiotensin-converting enzyme 2 (ACE2) is a key enzyme of the renin angiotensin system, which breaks down angiotensin II and forms angiotensin-(1-7). In erectile tissues, it has been documented that angiotensin II contributes to the development ...
Wiley-Blackwell2015Antihypertensive drugs metabolism: an update to pharmacokinetic profiles and computational approaches
Vassily Hatzimanikatis, Ljubisa Miskovic, Aikaterini Zisaki
Drug discovery and development is a high-risk enterprise that requires significant investments in capital, time and scientific expertise. The studies of xenobiotic metabolism remain as one of the main topics in the research and development of drugs, cosmet ...
Bentham Science Publishers2015Emerging Pharmacological Treatments to Prevent Abdominal Aortic Aneurysm Growth and Rupture
Nikolaos Stergiopoulos, Bram Trachet
Abdominal aortic aneurysm (AAA) is a local expansion of the abdominal aorta wall caused by a complex multifactorial maladaptive vascular remodeling. Despite recent advances in the management of cardiovascular diseases, there currently is no established dru ...
Bentham Science Publ Ltd2015Pathophysiological role of the renin-angiotensin system on erectile dysfunction
Background The renin-angiotensin system (RAS) has been shown to play an active role within the erectile tissues. The aim of this narrative review is to summarize the literature addressing the pathophysiological role of RAS on erectile function. Additionall ...
Wiley-Blackwell2013Opportunities for Targeting the Angiotensin-Converting Enzyme 2/Angiotensin-(1-7)/Mas Receptor Pathway in Hypertension
It is well known that the renin-angiotensin system (RAS) plays a pivotal role in the pathophysiology of cardiovascular diseases. This is well illustrated by the great success of ACE inhibitors and angiotensin (Ang) II AT(1) blockers in the treatment of hyp ...
Springer2013