Publications related to Adenylyl cyclase

Bicc1 Polymerization Regulates the Localization and Silencing of Bound mRNA

Daniel Constam, Benjamin Marcel Daniel Rothé, Lucía Carolina Leal Esteban, Séverine Marguerite Urfer, Florian Urs Bernet

Loss of the RNA-binding protein Bicaudal-C (Bicc1) provokes renal and pancreatic cysts as well as ectopic Wnt/beta-catenin signaling during visceral left-right patterning. Renal cysts are linked to defective silencing of Bicc1 target mRNAs, including adeny ...

American Society for Microbiology2015

W246(6.48) Opens a Gate for a Continuous Intrinsic Water Pathway during Activation of the Adenosine A(2A) Receptor

Horst Vogel, Shuguang Yuan, Zhenquan Hu

The question how G-protein-coupled receptors transduce an extracellular signal by a sequence of transmembrane conformational transitions into an intracellular response remains to be solved at molecular detail. Herein, we use molecular dynamics simulations ...

Wiley-V C H Verlag Gmbh2015

Restoring the Co Magnetic Moments at Interfacial Co-Porphyrin Arrays by Site-Selective Uptake of Iron

Harald Brune, Stefano Rusponi, Markus Etzkorn, Uta Schlickum, Sebastian Stepanow, Torsten Houwaart

Magnetochemistry recently emerged as a promising approach to control addressable spin arrays on surfaces. Here we report on the binding, spatial ordering, and magnetic properties of Fe on a highly regular Co-tetraphenylporphyrin (Co-TPP) template and highl ...

Amer Chemical Soc2015

Ligand-induced structural changes in the cyclic nucleotide-modulated potassium channel MloK1

Henning Paul-Julius Stahlberg

Cyclic nucleotide-modulated ion channels are important for signal transduction and pacemaking in eukaryotes. The molecular determinants of ligand gating in these channels are still unknown, mainly because of a lack of direct structural information. Here we ...

Springer Nature2014

A KcsA/MloK1 Chimeric Ion Channel Has Lipid-dependent Ligand-binding Energetics

Henning Paul-Julius Stahlberg

Background: The mechanism of ligand gating in physiologically important cyclic nucleotide-modulated channels is unknown. Results: We constructed and purified a chimeric ion channel with activity modulated by cAMP and used it to measure ligand-binding energ ...

American Society for Biochemistry & Molecular Biology (ASBMB)2014

Type 5 Adenylyl Cyclase Increases Oxidative Stress by Transcriptional Regulation of Manganese Superoxide Dismutase via the SIRT1/FoxO3a Pathway

Johan Auwerx

Background-For reasons that remain unclear, whether type 5 adenylyl cyclase (AC5), 1 of 2 major AC isoforms in heart, is protective or deleterious in response to cardiac stress is controversial. To reconcile this controversy we examined the cardiomyopathy ...

American Heart Association2013

Assembly of the Transmembrane Domain of E. coli PhoQ Histidine Kinase: Implications for Signal Transduction from Molecular Simulations

Matteo Dal Peraro, Thomas Lemmin

The PhoQP two-component system is a signaling complex essential for bacterial virulence and cationic antimicrobial peptide resistance. PhoQ is the histidine kinase chemoreceptor of this tandem machine and assembles in a homodimer conformation spanning the ...

Public Library Science2013

Vaccinia Virus Entry Is Followed by Core Activation and Proteasome-Mediated Release of the Immunomodulatory Effector VH1 from Lateral Bodies

Henning Paul-Julius Stahlberg, Lucia Reh

Host cell entry of vaccinia virus, the prototypic poxvirus, involves a membrane fusion event delivering the viral core and two proteinaceous lateral bodies (LBs) into the cytosol. Uncoating of viral cores is poorly characterized, and the composition and fu ...

Elsevier BV2013

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Adenylyl cyclase

Regulation of the mRNA silencing activity of Bicaudal-C

Bicc1 Polymerization Regulates the Localization and Silencing of Bound mRNA

W246(6.48) Opens a Gate for a Continuous Intrinsic Water Pathway during Activation of the Adenosine A(2A) Receptor

Restoring the Co Magnetic Moments at Interfacial Co-Porphyrin Arrays by Site-Selective Uptake of Iron

Ligand-induced structural changes in the cyclic nucleotide-modulated potassium channel MloK1

A KcsA/MloK1 Chimeric Ion Channel Has Lipid-dependent Ligand-binding Energetics

Type 5 Adenylyl Cyclase Increases Oxidative Stress by Transcriptional Regulation of Manganese Superoxide Dismutase via the SIRT1/FoxO3a Pathway

Functional Characterization of the Mouse Olfactory Receptor mOR256-17 in Live Cells

Assembly of the Transmembrane Domain of E. coli PhoQ Histidine Kinase: Implications for Signal Transduction from Molecular Simulations

Vaccinia Virus Entry Is Followed by Core Activation and Proteasome-Mediated Release of the Immunomodulatory Effector VH1 from Lateral Bodies

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Functional Characterization of the Mouse Olfactory Receptor mOR256-17 in Live Cells

A KcsA/MloK1 Chimeric Ion Channel Has Lipid-dependent Ligand-binding Energetics

Ligand-induced structural changes in the cyclic nucleotide-modulated potassium channel MloK1

Regulation of the mRNA silencing activity of Bicaudal-C

Vaccinia Virus Entry Is Followed by Core Activation and Proteasome-Mediated Release of the Immunomodulatory Effector VH1 from Lateral Bodies

W246(6.48) Opens a Gate for a Continuous Intrinsic Water Pathway during Activation of the Adenosine A(2A) Receptor

Type 5 Adenylyl Cyclase Increases Oxidative Stress by Transcriptional Regulation of Manganese Superoxide Dismutase via the SIRT1/FoxO3a Pathway

Bicc1 Polymerization Regulates the Localization and Silencing of Bound mRNA

Assembly of the Transmembrane Domain of E. coli PhoQ Histidine Kinase: Implications for Signal Transduction from Molecular Simulations

Restoring the Co Magnetic Moments at Interfacial Co-Porphyrin Arrays by Site-Selective Uptake of Iron