Publications related to Selective progesterone receptor modulator

Close and selective integration of carbon nanomaterials by cvd onto working microelectrodes of multi sensing electrochemical biosensors

Giovanni De Micheli, László Forró, Sandro Carrara, Arnaud Magrez, Irene Taurino

A method composing the following steps; (a) forming electrodes, (b) effecting a catalyst deposition onto some electrodes, (c) applying a CVD process for a selective growth of carbon nanomaterial onto the electrodes, (d) activating the nanomaterials. ...

2015

Bond-Selective and Mode-Specific Dissociation of CH3D and CH2D2 on Pt(111)

Rainer Beck, Hirokazu Ueta, Phil Morten Hundt, Maarten Eduard van Reijzen

Infrared laser excitation of partially deuterated methanes (CH3D and CH2D2) in a molecular beam is used to control their dissociative chemisorption on a Pt(111) single crystal and to determine the quantum state-resolved dissociation probabilities. The excl ...

American Chemical Society2015

The FDA-approved natural product dihydroergocristine reduces the production of the Alzheimer's disease amyloid-beta peptides

Patrick Fraering, Jianhua Liu, Jing Yu

Known gamma-secretase inhibitors or modulators display an undesirable pharmacokinetic profile and toxicity and have therefore not been successful in clinical trials for Alzheimer's disease (AD). So far, no compounds from natural products have been identifi ...

Nature Publishing Group2015

Molecular basis for the regulation of the nuclear receptor LRH-1

Kristina Schoonjans, Matthias Alexander Sokrates Stein

Liver receptor homolog-1 (LRH-1) is a nuclear receptor (NR) with diverse functions in development, differentiation and metabolism and has been extensively studied in the enterohepatic system. While initially described as an orphan NR, recent studies sugges ...

Current Biology Ltd2015

Challenges in the Discovery of Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors

Pierre Vogel, Somi Reddy Majjigapu

Since the discovery of indoleamine 2,3-dioxygenase 1 (IDO1) as an attractive target for anticancer therapy in 2003, the search for inhibitors has been intensely pursued both in academia and in pharmaceutical companies. Many novel IDO1 inhibitor scaffolds h ...

Amer Chemical Soc2015

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

Kristina Schoonjans, Alessia Perino

The systemic expression of the bile acid (BA) sensor farnesoid X receptor (FXR) has led to promising new therapies targeting cholesterol metabolism, triglyceride production, hepatic steatosis and biliary cholestasis. In contrast to systemic therapy, bile a ...

Nature Publishing Group2015

Total Syntheses of (−)-Mersicarpine, (−)-Scholarisine G, (+)-Melodinine E, (−)-Leuconoxine, (−)-Leuconolam, (−)-Leuconodine A, (+)-Leuconodine F, and (−)-Leuconodine C: Self-Induced Diastereomeric Anisochronism (SIDA) Phenomenon for Scholarisine G and Leuconodines A and C

Qian Wang, Jieping Zhu, Zhengren Xu

Enantioselective total syntheses of title natural products from a common cyclohexenone derivative (S)-18 were reported. Ozonolysis of (S)-18 afforded a stable diketo ester (R)-17 that was subsequently converted to two skeletally different natural products, ...

Amer Chemical Soc2015

Progesterone and Overlooked Endocrine Pathways in Breast Cancer Pathogenesis

Cathrin Brisken, Kathryn Hess Bellwald

Worldwide, breast cancer incidence has been increasing for decades. Exposure to reproductive hormones, as occurs with recurrent menstrual cycles, affects breast cancer risk, and can promote disease progression. Exogenous hormones and endocrine disruptors h ...

2015

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Selective progesterone receptor modulator

Close and selective integration of carbon nanomaterials by cvd onto working microelectrodes of multi sensing electrochemical biosensors

Bond-Selective and Mode-Specific Dissociation of CH3D and CH2D2 on Pt(111)

The FDA-approved natural product dihydroergocristine reduces the production of the Alzheimer's disease amyloid-beta peptides

Molecular basis for the regulation of the nuclear receptor LRH-1

Challenges in the Discovery of Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

Total Syntheses of (−)-Mersicarpine, (−)-Scholarisine G, (+)-Melodinine E, (−)-Leuconoxine, (−)-Leuconolam, (−)-Leuconodine A, (+)-Leuconodine F, and (−)-Leuconodine C: Self-Induced Diastereomeric Anisochronism (SIDA) Phenomenon for Scholarisine G and Leuconodines A and C

Identification of Soft Matter Binding Peptide Ligands Using Phage Display

Mechanisms underlying cell-fate determination in the mammary gland development

Progesterone and Overlooked Endocrine Pathways in Breast Cancer Pathogenesis

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Chat with Graph Search

Close and selective integration of carbon nanomaterials by cvd onto working microelectrodes of multi sensing electrochemical biosensors

Bond-Selective and Mode-Specific Dissociation of CH3D and CH2D2 on Pt(111)

The FDA-approved natural product dihydroergocristine reduces the production of the Alzheimer's disease amyloid-beta peptides

Molecular basis for the regulation of the nuclear receptor LRH-1

Progesterone and Overlooked Endocrine Pathways in Breast Cancer Pathogenesis

Challenges in the Discovery of Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

Identification of Soft Matter Binding Peptide Ligands Using Phage Display

Total Syntheses of (−)-Mersicarpine, (−)-Scholarisine G, (+)-Melodinine E, (−)-Leuconoxine, (−)-Leuconolam, (−)-Leuconodine A, (+)-Leuconodine F, and (−)-Leuconodine C: Self-Induced Diastereomeric Anisochronism (SIDA) Phenomenon for Scholarisine G and Leuconodines A and C

Mechanisms underlying cell-fate determination in the mammary gland development