Concept

Ribosome

Related publications (56)

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Towards a total synthesis of aminoacylated t-RNAs

In the ribosomal biosynthesis of proteins, the aminoacylated t-RNAs serve as carriers of the amino acids. A total synthesis of these biol. key-compds. would allow the site-specific incorporation of modifications within the t-RNA and attachment of any desir ...

2001

Bacterial Na+-ATP synthase has an undecameric rotor

Henning Paul-Julius Stahlberg, Andreas Engel

Synthesis of adenosine triphosphate (ATP) by the F1F0 ATP synthase involves a membrane-embedded rotary engine, the F-0 domain, which drives the extra-membranous catalytic F-1 domain. The F-0 domain consists of subunits a(1)b(2) and a cylindrical rotor asse ...

Wiley-Blackwell2001

Assembly of type 1 pili in Escherichia coli

Christian Heinis

An extensive random mutagenesis study on the function of nine residues in the subunit binding site of FimC was conducted to evaluate the mol. mechanisms of subunit binding by FimC and the contribution of chaperone surface residues. Five plasmid libraries o ...

Deutsche Akademie der Naturforscher Leopoldina2001

Brucella abortus transits through the autophagic pathway and replicates in the endoplasmic reticulum of nonprofessional phagocytes

Françoise Gisou van der Goot Grunberg

Brucella abortus is an intracellular pathogen that replicates within a membrane-bounded compartment. In this study, we have examined the intracellular pathway of the virulent B. abortus strain 2308 (S2308) and the attenuated strain 19 (S19) in HeLa cells. ...

1998

a-Deprotonated allyl ethers: conformational mobility and conformational preferences

Tert-BuLi is best suited to accomplish an H-metal exchange at the a-position of g-alkyl branched allyl ethers. Rapid torsional equilibration occurs at the g-terminus of the deprotonated allyl unit, while the alkoxy group at the a-site has to occupy the exo ...

1998

Streptomycin resistance in mycobacteria.

Stewart Cole

Streptomycin, the first antibiotic used in tuberculosis control programs, perturbs protein synthesis at the ribosome level. It is shown here that streptomycin resistance in some clinical isolates of Mycobacterium tuberculosis is associated either with miss ...

1994