Concept
Atropisomer
Related publications (36)
Recent advances in Rh(I)-catalyzed enantioselective C-H functionalization
Yi Zhang, Nicolai Cramer, Shouguo Wang, Zhen Chen
Chiral carbon-carbon (C-C) and carbon-heteroatom (C-X) bonds are pervasive and very essential in natural products, bioactive molecules, and functional materials, and their catalytic construction has emerged as one of the hottest research fields in syntheti ...
Cambridge2024Architecture-Controllable Single-Crystal Helical Self-assembly of Small-Molecule Disulfides with Dynamic Chirality
Beyond the common supramolecular helical polymers in solutions, controlling single-crystal helical self-assembly with precisely defined chirality and architectures has been challenging. Here, we report that simply merging static homochiral amino acids with ...
AMER CHEMICAL SOC2023A five-stranded heterometallic helicate
Kay Severin, Farzaneh Fadaei Tirani, Sylvain Alexandre Marie Sudan
A penta-stranded helicate was obtained by combining Pd(CH3CN)42 with La(NO3)3 and a polydentate ligand. The helicate displays low symmetry, both in solution and in the solid state. A dynamic interconversion between the penta-stranded helicate and a ...
2023Atropo‐Enantioselective Oxidation‐Enabled Iridium(III)‐Catalyzed C−H Arylations with Aryl Boronic Esters
Atropo-enantioselective biaryl coupling through C−H bond functionalization is an emerging technology allowing direct construction of axially chiral molecules. This approach is largely limited to electrophilic coupling partners. We report a highly atropo-en ...
2021Intermolecular Pd(0)-Catalyzed Atropo-enantioselective C-H Arylation of Heteroarenes and Other Investigations into the Enantioselective Activation of Challenging C(sp3)-H Bonds
The direct construction of stereogenic axes by enantioselective C-H arylation has been regarded as a very challenging transformation. Very few examples have been reported, despite the indisputable straight-forwardness of the methodology. This is due to the ...
EPFL2021Intermolecular Palladium(0)-Catalyzed Atropo-enantioselective C-H Arylation of Heteroarenes
Nicolai Cramer, Qui-Hien Nguyen
Atropisomeric (hetero)biaryls are motifs with increasing significance in ligands, natural products, and biologically active molecules. The straightforward construction of the stereogenic axis by efficient C-H functionalization methods is extremely rare and ...
2020