Concept

Recreational drug use

Related publications (83)

Development of Organometallic Ruthenium-Arene Anticancer Drugs That Resist Hydrolysis

Paul Joseph Dyson, Wee Han Ang, Claudine Scolaro, Elisa Daldini

With a view to develop drugs that could resist hydrolysis in aq. media,organometallic arene-capped ruthenium(II) 1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane (RAPTA) complexes bearing chelating carboxylate ligands have been prepd. and studied. The new com ...

2006

Drug loading of porous coating

Heinrich Hofmann, Laurent-Dominique Piveteau

Porous coating for the controlled release of drugs, said coating comprising a porous structure with pores adapted to act as reservoirs or as passages for a drug, in such a way that said drug can move from the external environment to/from or through said po ...

2006

Metal-based antitumour drugs in the post genomic era

Paul Joseph Dyson, Gianni Sava

The discovery of new metal-based antitumor drugs, whether cisplatin derivs. or those based on other metals, has been largely based on cell viability assays (IC50 values) and compds. that bind to DNA. This approach has been applied for more than 30 years du ...

2006

Duocarmycins binding to DNA explored by molecular simulation

Ursula Röthlisberger, Paolo Carloni

Duocarmycins are a potent class of antitumor agents. Their activity arises by their covalent binding to adenine nucleobases of DNA. We use classical mol. dynamics and hybrid (QM/MM) Car-Parrinello mol. dynamics simulations to study non-covalent and covalen ...

2005

Water-soluble prodrugs of cyclosporine A with tailored conversion rates

Arnaud Hamel

A novel type of water-soluble prodrugs of cyclosporine A (CsA) is described, featuring a modular system of an enzyme-cleavable group, a solubilizing moiety and a chemodegradable spacer attached to the hydroxyl function of (4R)-4-[(E)-2-butenyl]-4-,N-dimeth ...

2005

Solvatochromic Analysis of Partition Coefficients in the o-Nitrophenyl Octyl Ether (o-NPOE)/Water System

Hubert Girault, Pierre-Alain Carrupt, Natalie Muller

The objective of this study was to unravel the structural properties responsible for the partitioning of solutes in o‐nitrophenyl octyl ether (o‐NPOE)/H2O, a new solvent system for the determination of the partition coefficients of ions. A set of 88 compou ...

2003

Design of lattice proteins with explicit solvent

Paolo De Los Rios

Protein design is important to develop new drugs. As such, a knowledge of the correct model to use to design novel proteins is of the utmost importance. Here we show that a simple model where the solvent degrees of freedom are (semi)explicitly taken into a ...

2002

Role for human immunodeficiency virus type 1 membrane cholesterol in viral internalization

Didier Trono, Laurence Gouzi Abrami, Priscilla Turelli

The membrane of human immunodeficiency virus type 1 (HIV-1) virions contains high levels of cholesterol and sphingomyelin, an enrichment that is explained by the preferential budding of the virus through raft microdomains of the plasma membrane. Upon deple ...

2002

Diaquadihydroxohexakis(tri-tert-butoxysilanethiolato)octalithium(I)-toluene (1/2)

The title compd. was obtained by reaction of (tert-BuO)3SiSH with metallic Li. Crystals are monoclinic, space group P21/n, with a 13.088(3), b 27.188(5), c 17.525(4) .ANG., b 102.25(3) Deg; Z = 2, dc = 1.083; R = 0.036, Rw(F2) = 0.105 for 11,732 reflection ...

2002

Synthesis and biological properties of monothiosaccharides

Pierre Vogel, Inmaculada Robina

As other monosaccharide mimics such as the azasugars and the carbasugars (with nitrogen and carbon atom, respectively, instead of oxygen atom in the ring) the thiosugars (with sulfur atom instead of oxygen atom in the ring) have gained importance in glycob ...

2001

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