Concept
Glucose clamp technique
Related publications (26)
Lentiviral Transgenesis as a Tool to Study the Role of Uncoupling Protein Isoforms in the Nervous System
Hélène Danielle Perreten Lambert
A tight coupling exists between synaptic activity and glucose utilization by astrocytes. Metabolic cooperation between neurons and astrocytes mediates this coupling. During synaptic activation, glutamate that is released in the synaptic cleft as a neurotra ...
EPFL2011SIRT1 mRNA Expression May Be Associated with Energy Expenditure and Insulin Sensitivity
Johan Auwerx, Hiroyasu Yamamoto
Objective - Sirtuin 1 (SIRT1) is implicated in the regulation of mitochondrial function, energy metabolism, and insulin sensitivity in rodents. No studies are available in humans to demonstrate that SIRT1 expression in insulin sensitive tissues is associat ...
2010Deep thiopental anesthesia alters steady-state glucose homeostasis but not the neurochemical profile of rat cortex
Barbiturates are regularly used as an anesthetic for animal experimentation and clinical procedures and are frequently provided with solubilizing compounds, such as ethanol and propylene glycol, which have been reported to affect brain function and, in the ...
Wiley-Blackwell2010The rate-limiting step for glucose transport into the hypothalamus is across the blood–hypothalamus interface
Rolf Gruetter, Hongxia Lei, Carole Poitry-Yamate
Specialized glucosensing neurons are present in the hypothalamus, some of which neighbor the median eminence, where the blood–brain barrier has been reported leaky. A leaky blood–brain barrier implies high tissue glucose levels and obviates a role for endo ...
Wiley-Blackwell2009Evaluation of glucose homeostasis
Obesity and dyslipidemia are often found in association with insulin resistance (IR). These components combined with hypertension characterize the most common endocrine disorder in humans, the metabolic syndrome. Thus, in addition to profiling body weight ...
Wiley2007Visceral obesity is associated with high levels of serum squalene
OBJECTIVE: To investigate the impact of visceral obesity on cholesterol metabolism in normoglycemic offspring of patients with type 2 diabetes. RESEARCH METHODS AND PROCEDURES: The proportion of intra-abdominal fat (IAF) was measured by abdominal computer ...
2006Glucose sensitivity through oxidation responsiveness. An example of cascade-responsive nano-sensors
Jeffrey Alan Hubbell, Nicola Tirelli, Annemie Rehor
Oxidn.-sensitive nanoparticles have been decorated with an oxidizing enzyme (glucose oxidase) for release behavior that is responsive to the presence of the enzyme substrate (glucose). [on SciFinder (R)] ...
2005Dynamic or inert metabolism? Turnover of N-acetyl aspartate and glutathione from D-[1-13C]glucose in the rat brain in vivo
The rate of (13)C-label incorporation into both aspartyl (NAA C3) and acetyl (NAA C6) groups of N-acetyl aspartate (NAA) was simultaneously measured in the rat brain in vivo for up to 19 h of [1-(13)C]glucose infusion (n = 8). Label incorporation was detec ...
Wiley-Blackwell2004Glycogen: the forgotten cerebral energy store
The brain contains a significant amount of glycogen that is an order of magnitude smaller than that in muscle, but several-fold higher than the cerebral glucose content. Although the precise role of brain glycogen to date is unknown, it seems affected by f ...
Wiley-Blackwell2003In vivo measurements of brain glucose transport using the reversible michaelis-menten model and simultaneous measurements of cerebral blood flow changes during hypoglycemia
Glucose is the major substrate that sustains normal brain function. When the brain glucose concentration approaches zero, glucose transport across the blood-brain barrier becomes rate limiting for metabolism during, for example, increased metabolic activit ...
2001