Concept

Paleopolyploidy

Related publications (42)

Genomic context analysis reveals dense interaction network between vertebrate ultraconserved non-coding elements

Philipp Bucher, Slavica Dimitrieva Janeva

Motivation: Genomic context analysis, also known as phylogenetic profiling, is widely used to infer functional interactions between proteins but rarely applied to non-coding cis-regulatory DNA elements. We were wondering whether this approach could provide ...

Oxford University Press2012

Approximating the edit distance for genomes with duplicate genes under DCJ, insertion and deletion

Yu Lin, Mingfu Shao

Computing the edit distance between two genomes under certain operations is a basic problem in the study of genome evolution. The double-cut-and-join (DCJ) model has formed the basis for most algorithmic research on rearrangements over the last few years. ...

Biomed Central Ltd2012

A genetic approach to the transcriptional regulation of hox gene clusters

Denis Duboule

The evolution of vertebrate genomes was accompanied by an astounding increase in the complexity of their regulatory modalities. Genetic redundancy resulting from large-scale genome duplications at the base of the chordate tree was repeatedly exploited by t ...

2011

A new genomic evolutionary model for rearrangements, duplications, and losses that applies across eukaryotes and prokaryotes

Bernard Moret, Yu Lin

Genomic rearrangements have been studied since the beginnings of modern genetics and models for such rearrangements have been the subject of many papers over the last 10 years. However, none of the extant models can predict the evolution of genomic organiz ...

Mary Ann Liebert2011

MarcXimiL : near duplicates detection (and similarity analysis)

Alain Borel, Jan Brice Krause

MarcXimiL is an open source tool which works on MARCXML records and calculates similarity indices between these records. After a short theoretical introduction, the tutorial will focus on how to install, parametrize and use the tool. This tool can be imple ...

2011

Reshuffling genomic landscapes to study the regulatory evolution of Hox gene clusters

Denis Duboule

The emergence of Vertebrata was accompanied by two rounds of whole-genome duplications. This enabled paralogous genes to acquire novel functions with high evolutionary potential, a process suggested to occur mostly by changes in gene regulation, rather tha ...

2011

Massive Gene Duplication Event among Clinical Isolates of the Mycobacterium tuberculosis W/Beijing Family

Gaëlle Séraphine Kolly

As part of our effort to uncover the molecular basis for the phenotypic variation among clinical Mycobacterium tuberculosis isolates, we have previously reported that isolates belonging to the W/Beijing lineage constitutively overexpress the DosR-regulated ...

2010

A New Genomic Evolutionary Model for Rearrangements, Duplications, and Losses that Applies across Eukaryotes and Prokaryotes

Bernard Moret, Yu Lin

Springer Verlag New York2010

A New Genomic Evolutionary Model for Rearrangements, Duplications, and Losses That Applies across Eukaryotes and Prokaryotes

Bernard Moret, Yu Lin

Background: Genomic rearrangements have been studied since the beginnings of modern genetics and models for such rearrangements have been the subject of many papers over the last 10 years. However, none of the extant models can predict the evolution of gen ...

Springer Berlin Heidelberg2010

Genomic regulatory blocks encompass multiple neighboring genes and maintain conserved synteny in vertebrates

Andrew Charles Oates

We report evidence for a mechanism for the maintenance of long-range conserved synteny across vertebrate genomes. We found the largest mammal-teleost conserved chromosomal segments to be spanned by highly conserved noncoding elements (HCNEs), their develop ...

2007

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