Concept

Restriction enzyme

Related publications (169)

Structure-function analysis points to a polynucleotide-accommodating groove essential for APOBEC3A restriction activities

Didier Trono, Priscilla Turelli, Amalio Telenti, Shyam Sunder Peddi, Olivier Michielin

Members of the human APOBEC3 family of editing enzymes can inhibit various mobile genetic elements. APOBEC3A (A3A) can block the retrotransposon LINE-1 and the parvovirus adeno-associated virus type 2 (AAV-2) but does not inhibit retroviruses. In contrast, ...

American Society for Microbiology2010

What is the Relationship Between Fear of Falling and Gait in Well-Functioning Older Persons Aged 65 to 70 Years?

Kamiar Aminian

Rochat S, Büla CJ, Martin E, Seematter-Bagnoud L, Karmaniola A, Aminian K, Piot-Ziegler C, Santos-Eggimann B. What is the relationship between fear of falling and gait in well-functioning older persons aged 65 to 70 years? Objective: To investigate the ass ...

Elsevier2010

The carbon source governs the population dynamics of phosphate accumulating organisms in aerobic granules

Christof Holliger, Olivia Zanoletti, Samuel Lochmatter, Graciela Gonzalez Gil

Aerobic granules are quasi-spherical biofilms mainly composed of self-immobilized mixed microbial communities. The application of aerobic granules to treat domestic and low-strength industrial wastewaters is gaining attention because granules can accommoda ...

2010

Organometallic antitumour agents with alternative modes of action

Paul Joseph Dyson, Christian Hartinger, Angela Casini, Alexey Nazarov

The therapeutic index of drugs that target DNA, a ubiquitous target present in nearly all cells, is low. Nevertheless, DNA has remained the primary target for medicinal chemists developing metal-based anticancer drugs, although DNA has been essentially aba ...

2010

WHO IS INTERESTED IN THE REDUCTIVE DECHLORINATION OF POLYCHLORINATED BIPHENYLS (PCBs)?

Christof Holliger, Pierre Rossi, Martina Praveckova

PCBs are persistent organic pollutants which have entered the environment through both use and disposal. The environmental dissemination of PCBs is complex and nearly global in scale, although their production was banned in the 80’s. Nowadays, specific bac ...

2010

High-Throughput Screening of Enzymes by Retroviral Display Using Droplet-Based Microfluidics

Christoph Merten

During the last 25 years, display techniques such as phage display have become very powerful tools for protein engineering, especially for the selection of monoclonal antibodies. However, while this method is extremely efficient for affinity-based selectio ...

2010

A polymorphism in the HCP5 gene associated with HLA-B*5701 does not restrict HIV-1 in vitro

Jacques Fellay, Wei Huang

A single-nucleotide polymorphism (rs2395029) in the HCP5 gene associated with HLA-B*5701 is correlated with lower HIV-1 viral set point. The two allelic forms of coding region were ectopically expressed in TZM-bl cells for an effect on HIV-1 replication. N ...

2010

Transcriptional regulation of lipid homeostasis in mycobacteria

Stewart Cole, Claudia Sala

Mycolic acids are major components of the cell envelope of mycobacteria, such as Mycobacterium tuberculosis, and play an important role in its architecture, impermeability and interaction with the environment. Synthesis of mycolic acids is carried out by t ...

2010

Homing endonucleases: from basics to therapeutic applications

Homing endonucleases (HE) are double-stranded DNAses that target large recognition sites (12-40 bp). HE-encoding sequences are usually embedded in either introns or inteins. Their recognition sites are extremely rare, with none or only a few of these sites ...

Springer Verlag2009

THE CHOICE OF INOCULUM IS KEY FOR THE FORMATION OF DENSE FAST-SETTLING AEROBIC GRANULAR SLUDGE

Christof Holliger, Pierre Rossi, Emmanuelle Rohrbach, David Gregory Weissbrodt, Samuel Lochmatter, Sirous Ebrahimi, Sébastien Gabus

Aerobic granular sludge sequencing batch reactor (SBR) technology constitutes an attractive solution for the simultaneous removal of biodegradable carbonaceous (C), phosphorous (P) and nitrogenous (N) loads from food-industrial and municipal wastewaters. B ...

2009

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