Publications related to Translation (biology)

Enhancing mitochondrial proteostasis reduces amyloid-beta proteotoxicity

Johan Auwerx, Davide D'Amico, Adrian Schmid, Norman Lionel Moullan, Vincenzo Sorrentino, Hongbo Zhang, Francesca Potenza, Solene Rietsch

Alzheimer's disease is a common and devastating disease characterized by aggregation of the amyloid-beta peptide. However, we know relatively little about the underlying molecular mechanisms or how to treat patients with Alzheimer's disease. Here we provid ...

Nature Publishing Group2017

Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals

Johan Auwerx, Davide D'Amico

Mitochondrial stress activates a mitonuclear response to safeguard and repair mitochondrial function and to adapt cellular metabolism to stress. Using a multiomics approach in mammalian cells treated with four types of mitochondrial stressors, we identify ...

Rockefeller Univ Press2017

Genetic and epigenetic inactivation of SESTRIN1 controls mTORC1 and response to EZH2 inhibition in follicular lymphoma

Elisa Oricchio, Natalya Katanayeva, Elena Battistello, Stephanie Jocelyne Sungalee, Maria Christine Donaldson, Giovanni Ciriello

Follicular lymphoma (FL) is an incurable form of B cell lymphoma. Genomic studies have cataloged common genetic lesions in FL such as translocation t(14;18), frequent losses of chromosome 6q, and mutations in epigenetic regulators such as EZH2 Using a focu ...

American Association for the Advancement of Science2017

Preclinical Evaluation of Photoacoustic Imaging as a Novel Noninvasive Approach to Detect an Orthopaedic Implant Infection

Riccardo Sinisi, Pavlo Khodakivskyi, Ghyslain Martial Alain Budin

Introduction: Diagnosing-prosthetic joint infection (PJI) poses significant challenges, and current modalities are fraught with low sensitivity and/or potential morbidity. Photoacoustic imaging (PAI) is a novel ultrasound-based modality with potential for ...

Lippincott Williams & Wilkins2017

Analysis of Translation Elongation Dynamics in the Context of an Escherichia coli Cell

Vassily Hatzimanikatis, Julien Racle, Joana Raquel Pinto Vieira

Understanding the mechanisms behind translation and its rate-limiting steps is crucial for both the development of drug targets and improvement of heterologous protein production with many biotechnological applications, such as in pharmaceutical and biofue ...

Elsevier2016

Analysis of Translation Elongation Dynamics in the Context of an Escherichia coli Cell

Vassily Hatzimanikatis, Julien Racle, Joana Raquel Pinto Vieira

Elsevier2016

Olfactory receptor pseudo-pseudogenes

Matteo Dal Peraro, Benoîte Bargeton

Pseudogenes are generally considered to be non-functional DNA sequences that arise through nonsense or frame-shift mutations of protein-coding genes(1). Although certain pseudogene-derived RNAs have regulatory roles(2), and some pseudogene fragments are tr ...

Nature Publishing Group2016

Phage selection of peptide macrocycles against b-catenin to interfere with Wnt signaling

Christian Heinis, Pierre Vincent Dessen, Davide Bertoldo, Maola Khan Mohammad Golam

Upregulation of b-catenin, the primary mediator of the Wnt signaling pathway, plays an important role in the tumorigenesis of several types of human cancer. Targeting b-catenin to interfere with its ability to serve as a translational co-activator is consi ...

2016

Noise analysis of genome-scale protein synthesis using a discrete computational model of translation

Vassily Hatzimanikatis, Julien Racle, Adam Stefaniuk

Noise in genetic networks has been the subject of extensive experimental and computational studies. However, very few of these studies have considered noise properties using mechanistic models that account for the discrete movement of ribosomes and RNA pol ...

Amer Inst Physics2015

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Translation (biology)

Enhancing mitochondrial proteostasis reduces amyloid-beta proteotoxicity

Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals

Genetic and epigenetic inactivation of SESTRIN1 controls mTORC1 and response to EZH2 inhibition in follicular lymphoma

Preclinical Evaluation of Photoacoustic Imaging as a Novel Noninvasive Approach to Detect an Orthopaedic Implant Infection

Analysis of Translation Elongation Dynamics in the Context of an Escherichia coli Cell

Analysis of Translation Elongation Dynamics in the Context of an Escherichia coli Cell

Olfactory receptor pseudo-pseudogenes

Phage selection of peptide macrocycles against b-catenin to interfere with Wnt signaling

Translating Hedgehog in Cancer: Controlling Protein Synthesis

Noise analysis of genome-scale protein synthesis using a discrete computational model of translation

Graph Chatbot

Chat with Graph Search

Genetic and epigenetic inactivation of SESTRIN1 controls mTORC1 and response to EZH2 inhibition in follicular lymphoma

Enhancing mitochondrial proteostasis reduces amyloid-beta proteotoxicity

Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals

Preclinical Evaluation of Photoacoustic Imaging as a Novel Noninvasive Approach to Detect an Orthopaedic Implant Infection

Analysis of Translation Elongation Dynamics in the Context of an Escherichia coli Cell

Analysis of Translation Elongation Dynamics in the Context of an Escherichia coli Cell

Olfactory receptor pseudo-pseudogenes

Noise analysis of genome-scale protein synthesis using a discrete computational model of translation

Translating Hedgehog in Cancer: Controlling Protein Synthesis

Phage selection of peptide macrocycles against b-catenin to interfere with Wnt signaling