Concept

Restriction fragment length polymorphism

Related publications (96)

A polymorphism in the HCP5 gene associated with HLA-B*5701 does not restrict HIV-1 in vitro

A single-nucleotide polymorphism (rs2395029) in the HCP5 gene associated with HLA-B*5701 is correlated with lower HIV-1 viral set point. The two allelic forms of coding region were ectopically expressed in TZM-bl cells for an effect on HIV-1 replication. N ...

2010

Occurrence of microcystin-producing cyanobacteria in Ugandan freshwater habitats

Cyril Portmann, Karl Gademann

Microcystins (MCs) are cyclic heptapeptides, which are the most abundant toxins produced by cyanobacteria in freshwater. The phytoplankton of many freshwater lakes in Eastern Africa is dominated by cyanobacteria. Less is known, however, on the occurrence o ...

2010

Study of the microbial communities of core and water samples in a chloroethenes contaminated aquifer

Guillaume Laulan

Widely used in industrial activities, chloroethenes have become common groundwater contaminants. Dehalorespiration is an anaerobic bacterial respiration coupling their sequential degradation to energy production. The interactions between the dehalorespirin ...

2009

Statistical assessment of the variability of the T-RFLP analysis applied to complex microbial communities

Christof Holliger, Pierre Rossi, Emmanuelle Rohrbach, François Gillet

The variability of the T-RFLP analysis applied to complex microbial communities was assessed statistically. Recent technological improvements were implemented in the successive steps of the procedure, resulting in a standardized procedure which provided a ...

American Society for Microbiology2009

THE CHOICE OF INOCULUM IS KEY FOR THE FORMATION OF DENSE FAST-SETTLING AEROBIC GRANULAR SLUDGE

Christof Holliger, Pierre Rossi, Emmanuelle Rohrbach, David Gregory Weissbrodt, Samuel Lochmatter, Sirous Ebrahimi, Sébastien Gabus

Aerobic granular sludge sequencing batch reactor (SBR) technology constitutes an attractive solution for the simultaneous removal of biodegradable carbonaceous (C), phosphorous (P) and nitrogenous (N) loads from food-industrial and municipal wastewaters. B ...

2009

Lack of Insertional-Deletional Polymorphism in a Collection of Mycobacterium ulcerans Isolates from Ghanaian Buruli Ulcer Patients

Stewart Cole, Julia Hauser

Mycobacterium ulcerans causes the devastating infectious skin disease Buruli ulcer and has a monomorphic population structure. The resolution of conventional genetic fingerprinting methods is therefore not sufficient for microepidemiological studies aiming ...

American Society for Microbiology2009

Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance

Jacques Fellay

Chronic infection with hepatitis C virus (HCV) affects 170 million people worldwide and is the leading cause of cirrhosis in North America. Although the recommended treatment for chronic infection involves a 48-week course of peginterferon-alpha-2b (PegIFN ...

2009

Mycobacterium leprae genotype amplified from an archaeological case of lepromatous leprosy in Central Asia

Stewart Cole

We have amplified Mycobacterium leprae DNA from the skeleton of an adult human female exhibiting signs of lepromatous leprosy (LL). The remains were excavated from the site of Devkesken 6 on the Ustyurt plateau of Uzbekistan and date to between the 1st and ...

2009

Common genetic variation and the control of HIV-1 in humans

Jacques Fellay, Patrick Descombes, Amalio Telenti

To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the ...

2009

Are variable-number tandem repeats appropriate for genotyping Mycobacterium leprae?

Stewart Cole

Comparative genomics analysis of the Tamil Nadu strain of Mycobacterium leprae has uncovered several polymorphic sites with potential as epidemiological tools. In this study we compared the stability of two different markers of genomic biodiversity of M. l ...

2008

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